Unique ID issued by UMIN | UMIN000021078 |
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Receipt number | R000024301 |
Scientific Title | Activation of TRPM8 with cooling and application of menthol can reduce propofol injection-induced pain |
Date of disclosure of the study information | 2016/02/17 |
Last modified on | 2019/08/29 13:05:08 |
Activation of TRPM8 with cooling and application of menthol can reduce propofol injection-induced pain
Activation of TRPM8 with cooling and application of menthol can reduce propofol injection-induced pain
Activation of TRPM8 with cooling and application of menthol can reduce propofol injection-induced pain
Activation of TRPM8 with cooling and application of menthol can reduce propofol injection-induced pain
Japan |
The patient whowere scheduled for elective surgery under anesthesia in our hospital.
Anesthesiology |
Others
NO
Injection of propofol has a high potential to induce intense burning pain. Since skin cooling is known to reduce burning pain originated from both the skin and deep tissue, and since the analgesic effect of skin cooling is known to depend on the activation of transient receptor potential M8 (TRPM8), we hypothesised that cooling the skin can prevent propofol injection-induced pain via activation of TRPM8 in the skin.
We first examined whether cooling of the skin can prevent propofol injection-induced pain or not. If so, we then would try to examine whether application of topical TRPM8 agonist (menthol) on the skin can prevent propofol injection-induced pain or not.
Efficacy
During the injection of propofol,we assess the incidence and intensity of propofol injection-induced pain and a 4-point numerical rating scales.
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
4
Treatment
Medicine | Other |
In Group non-cooling, a cooling gel pad stored at room temperature was applied on the left side of forearm.
In Group cooling, a cooling gel pad stored at 7 degree was applied on the left side of forearm.
In Group menthol, 1 ml of 30% menthol dissolved in 70% ethanol was applied to the left side of forearm.
In Group solvent, 1 ml of 70% ethanol was applied to the left side of forearm.
20 | years-old | <= |
Not applicable |
Male and Female
Planned operation patient under the general anesthesia.
1.Patients administered an analgesic before operation.
2.Patients have an allergy to propofol.
3.Patients have an allergy to ethanol.
4.Patients who have a skin disease to the arms.
120
1st name | Takashi |
Middle name | |
Last name | Ishida |
Shinshu University
Department of Anesthesiology and Resuscitology
3908621
3-1-1 Asahi, Matsumoto, Nagano
0263-37-2670
tisd@shinshu-u.ac.jp
1st name | Maiko |
Middle name | |
Last name | Suzuki |
Shinshu University
Department of Anesthesiology and Resuscitology
3908621
3-1-1 Asahi, Matsumoto, Nagano
0263-37-2670
mmw@shinshu-u.ac.jp
Shinshu University School of Medicine
Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine
Other
Shinshu University Certified Review Board of Clinical Research
3-1-1 Asahi, Matsumoto, Nagano
0263-37-2572
mdrinri@shinshu-u.ac.jp
NO
2016 | Year | 02 | Month | 17 | Day |
Unpublished
120
Completed
2016 | Year | 02 | Month | 03 | Day |
2016 | Year | 02 | Month | 03 | Day |
2016 | Year | 02 | Month | 22 | Day |
2017 | Year | 02 | Month | 22 | Day |
2016 | Year | 02 | Month | 17 | Day |
2019 | Year | 08 | Month | 29 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024301
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