Unique ID issued by UMIN | UMIN000021718 |
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Receipt number | R000025051 |
Scientific Title | Efficacy of multidrug-resistant Lactobacillus preparation on variation of intestinal bacterial flora caused by antibiotic therapy |
Date of disclosure of the study information | 2016/05/02 |
Last modified on | 2021/02/15 11:25:06 |
Efficacy of multidrug-resistant Lactobacillus preparation on variation of intestinal bacterial flora caused by antibiotic therapy
Efficacy of multidrug-resistant Lactobacillus preparation on variation of intestinal bacterial flora caused by antibiotic therapy
Efficacy of multidrug-resistant Lactobacillus preparation on variation of intestinal bacterial flora caused by antibiotic therapy
Efficacy of multidrug-resistant Lactobacillus preparation on variation of intestinal bacterial flora caused by antibiotic therapy
Japan |
Orthopedic disease
Infectious disease | Orthopedics | Adult |
Others
NO
To investigate the efficacy of multidrug-resistant Lactobacillus preparation on the variety of intestinal bacterial flora caused by antibiotic therapy
Efficacy
A variety of intestinal bacterial flora
Digestive symptom, property of stool, stool frequency, and postoperative complication
Interventional
Parallel
Randomized
Individual
Open -but assessor(s) are blinded
No treatment
2
Prevention
Medicine |
Administration of multidrug-resistant lactobacillus preparation
Control
20 | years-old | <= |
Not applicable |
Male and Female
Patients who will undergo surgery in the Department of Orthopedic Surgery
1. Allergy for Lactobacillus preparation
2. Patients who were treated with antibiotics within one month before hospitalization
3. Patients who were treated with lactobacillus preparation within one month before hospitalization
4. Patients with inflammatory bowel disease.
5. Pregnancy
6. for whom the attending doctor considerd he or she is not appropriate for the study.
40
1st name | Katsunori |
Middle name | |
Last name | Yanagihara |
Nagasaki University Hospital
Department of Laboratory Medicine
852-8501
1-7-1 Sakamoto, Nagasaki city
095-819-7574
k-yanagi@nagasaki-u.ac.jp
1st name | Norihito |
Middle name | |
Last name | Kaku |
Nagasaki University Hospital
Department of Laboratory Medicine
852-8501
1-7-1 Sakamoto, Nagasaki city
095-819-7574
kaku-ngs@umin.ac.jp
Nagasaki University
Biofermin pharmaceutical Co., Ltd.
Profit organization
Nagasaki University Hospital
1-7-1, Sakamoto, Nagasaki City
095-819-7217
gaibushikin@ml.nagasaki-u.ac.jp
NO
2016 | Year | 05 | Month | 02 | Day |
https://www.sciencedirect.com/science/article/pii/S1341321X20300970?via%3Dihub
Published
https://www.jiac-j.com/article/S1341-321X(20)30097-0/fulltext
33
There was no significant difference between the groups regarding patient characteristics. In alpha and beta diversity, there were no significant differences among all combinations. In differential abundance analysis at operational taxonomic unit level, Streptococcus gallolyticus and Roseburia were significantly increased in the non-probiotics group and significantly decreased in the probiotics group.
2020 | Year | 10 | Month | 30 | Day |
2020 | Year | 04 | Month | 10 | Day |
The patients who underwent spinal surgery at Nagasaki University Hospital
After obtaining informed consent, the patients were automatically classified into the non-probiotics group and the probiotics group.
None
Comparison of a change of stool microbiome by administration of surgical antibiotic prophylaxis between control and probiotics groups
Completed
2016 | Year | 04 | Month | 25 | Day |
2016 | Year | 04 | Month | 26 | Day |
2016 | Year | 07 | Month | 04 | Day |
2018 | Year | 03 | Month | 30 | Day |
2018 | Year | 03 | Month | 30 | Day |
2018 | Year | 06 | Month | 30 | Day |
2018 | Year | 08 | Month | 31 | Day |
2016 | Year | 03 | Month | 31 | Day |
2021 | Year | 02 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000025051
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