Unique ID issued by UMIN | UMIN000021770 |
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Receipt number | R000025105 |
Scientific Title | Analysis of renal expression of LRG-1 (leucine-rich alpha-2-glycoprotein 1) in pathophysiology of kidney disease |
Date of disclosure of the study information | 2016/04/05 |
Last modified on | 2016/04/04 16:53:36 |
Analysis of renal expression of LRG-1 (leucine-rich alpha-2-glycoprotein 1) in pathophysiology of kidney disease
Analysis of LRG1 expression in kidney disease
Analysis of renal expression of LRG-1 (leucine-rich alpha-2-glycoprotein 1) in pathophysiology of kidney disease
Analysis of LRG1 expression in kidney disease
Japan |
Kidney disease, hypertension, cardiovascular disease
Medicine in general | Cardiology | Nephrology |
Others
YES
This study will examine the distribution of LRG1 in the normal kidney tissues of dissected kidney by nephrectomy and in the renal biopsy specimens derived from diseased kidney, and investigate a putative role of LRG1 in renal physiology and pathophysiology.
Others
Exploratory
Not applicable
The distribution of LRG1 in the normal kidney tissues of dissected kidney by nephrectomy and in the renal biopsy specimens derived from diseased kidney, and its relationship with parameters of renal function, CKD CGA classification, diabetic nephropathy classification, and renal events (serum creatinine doubling, dialysis induction and total mortality.
Parameters of renal and cardiovascular function, glucose, lipid and electrolyte metabolism, renin-angiotensin system, urinary fibrotic and inflammatory factors, and ambulatory blood pressure monitoring.
Observational
Not applicable |
Not applicable |
Male and Female
1. Patients who are going to undergo renal biopsy for the scrutiny of kidney disease, and those who already underwent renal biopsy for the same purpose.
2. Patients who already underwent nephrectomy and whose resected renal tissues are preserved in the tissue repository.
Patients who are considered inappropriate for inclusion in the study.
120
1st name | |
Middle name | |
Last name | Kouichi TAMURA |
Yokohama City University Graduate School of Medicine
Department of Medical Science and Cardiorenal Medicine
3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JAPAN
045-787-2800
tamukou@med.yokohama-cu.ac.jp
1st name | |
Middle name | |
Last name | Dr. Sona Haku |
Yokohama City University Graduate School of Medicine
Department of Medical Science and Cardiorenal Medicine
3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JAPAN
045-787-2635
t106048f@yokohama-cu.ac.jp
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
Self funding
NO
横浜市立大学附属病院
2016 | Year | 04 | Month | 05 | Day |
Unpublished
2016 | Year | 04 | Month | 04 | Day |
2016 | Year | 04 | Month | 05 | Day |
2021 | Year | 02 | Month | 28 | Day |
2021 | Year | 02 | Month | 28 | Day |
2021 | Year | 02 | Month | 28 | Day |
2021 | Year | 02 | Month | 28 | Day |
1. Aim of the study
This study will examine the distribution of LRG1 in the normal kidney tissues of dissected kidney by nephrectomy and in the renal biopsy specimens derived from diseased kidney, and investigate a putative role of LRG1 in renal physiology and pathophysiology.
2. Study patients
(1) Inclusion criteria
1) Patients who are going to undergo renal biopsy for the scrutiny of kidney disease, and those who already underwent renal biopsy for the same purpose.
2) Patients who already underwent nephrectomy and whose resected renal tissues are preserved in the tissue repository.
(2) Exclusion criteria
1) Patients who are considered inappropriate for inclusion in the study.
3. Study design, number of participants and study duration
(1) Study design
The study includes prospective and retrospective cohort analysis.
(2) Number of participants
N=120.
(3) Study duration
From April 5, 2016 to February 28, 2021.
4. Outcomes
(1) Primary outcomes
The distribution of LRG1 in the normal kidney tissues of dissected kidney by nephrectomy and in the renal biopsy specimens derived from diseased kidney, and its relationship with parameters of renal function, CKD CGA classification, diabetic nephropathy classification, and renal events (serum creatinine doubling, dialysis induction and total mortality).
(2) Secondary outcomes
Parameters of renal and cardiovascular function, glucose, lipid and electrolyte metabolism, activity of renin-angiotensin system, fibrosis and inflammation, and ambulatory blood pressure monitoring.
2016 | Year | 04 | Month | 04 | Day |
2016 | Year | 04 | Month | 04 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000025105
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