Unique ID issued by UMIN | UMIN000021872 |
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Receipt number | R000025220 |
Scientific Title | Effects of flurbiprofen on the hypotension following to thoracotomy. |
Date of disclosure of the study information | 2016/04/11 |
Last modified on | 2017/03/30 14:29:35 |
Effects of flurbiprofen on the hypotension following to thoracotomy.
Effects of flurbiprofen on the hypotension following to thoracotomy.
Effects of flurbiprofen on the hypotension following to thoracotomy.
Effects of flurbiprofen on the hypotension following to thoracotomy.
Japan |
Elective lung resection cases
Chest surgery |
Malignancy
NO
In the elective lung resection surgery, we study if flurbiprofen adiministration is abele to suppress the hypotension following to thoracotomy and re-expansion or not.
Efficacy
Confirmatory
Pragmatic
Not applicable
Intraoperative blood pressure
Intraoperative heart rate
Intraoperative dose of phenylephrine and ephedrine
Intraoperative infusion, transufusion, urine output, blood loss and fluid balance (ml/kg/h)
Postoperative dose of flurbiprofen.
Postoperative dose of phenylephrine.
Postoperative infusion, transufusion, urine output, blood loss and fluid balance (ml/kg/h).
Count of blood cells(WBC, RBC, hemoglobin, platelets) and biochemical tests (Alb, AST, ALP, LDH, BUN, Cr, CRP) on 1 and 7 postoperative day.
ICU stay days.
Hospital stay days.
Interventional
Parallel
Randomized
Individual
Single blind -participants are blinded
Active
NO
NO
Institution is considered as a block.
NO
No need to know
2
Treatment
Medicine |
Flurubiprofen administration on anesthesia induction
Flurbiprofen administration on wound closure
20 | years-old | < |
90 | years-old | >= |
Male and Female
Elective lung resection cases scheduled for left thoracotomy
History of flurbiprofen allergy
Active asthma
Chronic kidney disease
60
1st name | |
Middle name | |
Last name | Hiroki Katoh |
Hyogo Cancer Center
Department of Anesthesia
13-70 Kitaoji Akashi
0789291151
whoami@hp.pref.hyogo.jp
1st name | |
Middle name | |
Last name | Hiromi Katoh |
Hyogo Cancer Center
Department of Anesthesia
13-70 Kitaoji Akashi
0789291151
whoami@hp.pref.hyogo.jp
Hyogo Cancer Center
Department of Anesthesia
Hyogo Cancer Center
Department of Anesthesia
Self funding
Japan
NO
兵庫県立がんセンター
2016 | Year | 04 | Month | 11 | Day |
Published
https://confit.atlas.jp/guide/event/jsa64/static/64th_program
In contrast to the significant hypotension in control group, flurbiprofen pretreatment maintained blood pressure after thoracotomy and
nondependent lung collapse. Dose of phenylephrine was significantly less in the flurbiprofen group for 10 to 60 minutes after thoracotomy. These results suggest that prostaglandin may correlate to the post thoracotomy hypotension.
Completed
2016 | Year | 03 | Month | 09 | Day |
2016 | Year | 04 | Month | 12 | Day |
2017 | Year | 03 | Month | 30 | Day |
2017 | Year | 03 | Month | 30 | Day |
2017 | Year | 03 | Month | 30 | Day |
2017 | Year | 03 | Month | 30 | Day |
2016 | Year | 04 | Month | 11 | Day |
2017 | Year | 03 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000025220
Research Plan | |
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Registered date | File name |
Research case data specifications | |
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Registered date | File name |
Research case data | |
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Registered date | File name |
2017/03/30 | FLU_集計.numbers |