Unique ID issued by UMIN | UMIN000022326 |
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Receipt number | R000025712 |
Scientific Title | Investigation of correlation between the findings of contrast-enhanced ultrasound and clinicopathological factors in breast cancer. |
Date of disclosure of the study information | 2016/05/17 |
Last modified on | 2016/05/17 18:16:25 |
Investigation of correlation between the findings of contrast-enhanced ultrasound and clinicopathological factors in breast cancer.
Investigation of correlation between the findings of contrast-enhanced ultrasound and clinicopathological factors in breast cancer.
Investigation of correlation between the findings of contrast-enhanced ultrasound and clinicopathological factors in breast cancer.
Investigation of correlation between the findings of contrast-enhanced ultrasound and clinicopathological factors in breast cancer.
Japan |
Breast cancer
Breast surgery |
Malignancy
NO
In breast cancer, there is no examination of the correlation between extended enhancement characteristics or enhancement intensity in contrast-enhanced ultrasound (CEUS) used Sonazoid and histopathological disease parameters . For this reason, these characteristics in CEUS were focused on in this study. The correlation between enhancement size compared with the original tumor size measured by plain B-mode imaging or enhancement intensity relative to surrounding normal breast tissue and estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor type 2 (HER2) expression, subtypes, nuclear grade, and Ki67 index was studied retrospectively, and whether CEUS would contribute to the presumption of high proliferating potential in breast cancer was investigated.
Efficacy
Exploratory
Others
Not applicable
To investigate the correlation between CEUS characteristics, enhancement size compared with the original tumor size measured by plain B-mode imaging or enhancement intensity relative to surrounding normal breast tissue and grade of breast cancer indicating by nuclear grade and Ki67 index.
1. To analysis the correlation between CEUS characteristics, enhancement size compared with the original tumor size measured by plain B-mode imaging or enhancement intensity relative to surrounding normal breast tissue and age, tumor diameter, axillary lymph node metastasis, ER, PgR, HER2 expression, subtypes.
2. In surgical specimen, to investigate HE staining histopathological image in extended enhancement region and boundary region of equal or smaller enhancement.
Observational
Not applicable |
Not applicable |
Male and Female
1. Patients with breast cancer who underwent CEUS in Ebetsu City Hospital.
2. Patients with histopathologically confirmed breast cancer who underwent mastectomy or breast-conserving surgery in Ebetsu City Hospital.
1. Patients who underwent neoadjuvant chemotherapy.
2. Patients who did not undergo surgery.
3. Ineligible patients certified by principal investigator.
50
1st name | |
Middle name | |
Last name | Masatoshi Kadoya |
Ebetsu City Hospital
Surgery
6, Wakakusa-cho, Ebetsu-shi, Hokkaido, Japan
011-382-5151
mkado.6809@kib.biglobe.ne.jp
1st name | |
Middle name | |
Last name | Masatoshi Kadoya |
Ebetsu City Hospital
Surgery
6, Wakakusa-cho, Ebetsu-shi, Hokkaido, Japan
011-382-5151
mkado.6809@kib.biglobe.ne.jp
Ebetsu City Hospital
None
Self funding
NO
2016 | Year | 05 | Month | 17 | Day |
Unpublished
Completed
2013 | Year | 09 | Month | 20 | Day |
2013 | Year | 10 | Month | 01 | Day |
Histopathological results from 45 patients with breast cancer who had undergone surgery after CEUS between October 2013 and November 2015 in Ebetsu City Hospital, who met all of inclusion criteria and was not applicable to all of exclusion criteria, were investigated retrospectively.
2016 | Year | 05 | Month | 16 | Day |
2016 | Year | 05 | Month | 17 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000025712
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