Unique ID issued by UMIN | UMIN000022336 |
---|---|
Receipt number | R000025740 |
Scientific Title | Observational study of metabolic factors associated with eGFR decline in participants with health checkups |
Date of disclosure of the study information | 2016/05/20 |
Last modified on | 2017/05/22 14:57:11 |
Observational study of metabolic factors associated with eGFR decline in participants with health checkups
Observational study of metabolic factors associated with eGFR decline in participants with health checkups
Observational study of metabolic factors associated with eGFR decline in participants with health checkups
Observational study of metabolic factors associated with eGFR decline in participants with health checkups
Japan |
chronic kidney disease, lifestyle-related disease
Medicine in general | Endocrinology and Metabolism | Nephrology |
Others
NO
The aim of this study was to investigate the factors associated with an eGFR decline in one year, especially metabolic factors which are strongly affected by individual lifestyle, in Japanese people who received annual health checkup.
Others
Observational study
Exploratory
Others
Not applicable
change in eGFR
Observational
Not applicable |
Not applicable |
Male and Female
Individuals who received at least two annual health checkups in Keio University Hospital.
Individuals with eGFR < 15 ml/min/1.73m2 (CKD stage G5) are excluded from the study.
2000
1st name | |
Middle name | |
Last name | Michiyo Takayama |
Keio University School of Medicine
Preventive Medicine
35 Shinanomachi Shinjuku-ku Tokyo Japan
03-3353-1211
michiyo@z6.keio.jp
1st name | |
Middle name | |
Last name | Kaori Hayashi |
Keio University School of Medicine
Preventive Medicine
35 Shinanomachi Shinjuku-ku Tokyo Japan
03-3353-1211
kaorihayashi@keio.jp
Department of Preventive Medicine, Keio University School of Medicine
self-funding
Self funding
NO
2016 | Year | 05 | Month | 20 | Day |
Published
Low HDL-C and ApoA1 levels significantly correlated with eGFR decline in a short period of one year. Metabolic syndrome also showed a significant association with eGFR decline. This study suggests the importance of hypertension and low HDL-C in the effect of metabolic syndrome on eGFR decline rather than obesity in non-CKD population.
Completed
2013 | Year | 01 | Month | 01 | Day |
2013 | Year | 01 | Month | 01 | Day |
2015 | Year | 12 | Month | 31 | Day |
2015 | Year | 12 | Month | 31 | Day |
Study design: Cross-sectional study. Individuals who received health checkup from Jan 1st in 2013 and did not meet the exclusion criteria have been enrolled. We examined blood pressure, body mass index (BMI, kg/m2), and waist circumference at the level of the navel during minimal respiration. All participants completed a self-administered questionnaire which documented medical history, medication, smoking habit, alcohol consumption habit, the frequency and intensity of daily exercise, eating habits, and sleeping habit. Serum makers including triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipoprotein A (Lp(a)), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), glucose, hemoglobin A1c (HbA1c), homeostatic model assessment of insulin resistance (HOMA-R), uric acid (UA), and highly-sensitive C reactive protein (hs-CRP) were measured. We examined urinary protein and blood excretion in urine samples using dipstick testing. Visceral fat area (VFA) was measured at the navel level using a single-slice CT scan.
2016 | Year | 05 | Month | 17 | Day |
2017 | Year | 05 | Month | 22 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000025740
Research Plan | |
---|---|
Registered date | File name |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |