Unique ID issued by UMIN | UMIN000022380 |
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Receipt number | R000025791 |
Scientific Title | The effects of 6% hydroxyethyl starch on ischemia-reperfusion injury in total knee replacement surgery with tourniquet application |
Date of disclosure of the study information | 2016/05/20 |
Last modified on | 2016/05/24 13:54:50 |
The effects of 6% hydroxyethyl starch on ischemia-reperfusion injury in total knee replacement surgery with tourniquet application
Can 6% hydroxyethyl starch solution reduce ischemic reperfusion injury from pneumatic tourniqutte application
The effects of 6% hydroxyethyl starch on ischemia-reperfusion injury in total knee replacement surgery with tourniquet application
Can 6% hydroxyethyl starch solution reduce ischemic reperfusion injury from pneumatic tourniqutte application
Asia(except Japan) |
6% hydroxyethyl starch, tourniqutte application, total knee arthroplasty, ischemic-reperfusion syndrome
Anesthesiology |
Others
NO
In patients receiving total knee arthroplasty using tourniqutte, we hypothesize that preoperative infusion of 6% hydroxyethyl starch solution can reduce ischemic reperfusion synfrome.
Efficacy
Exploratory
Others
Not applicable
Difference of serum malondialdehide level before and after tourniqutte application in each group, 6% hydroxyethyl starch group and normal saline group.
Differences of serum malondialdehide between the groups, 6%hydroxyethyl starch and normal saline group before and after tourniqutte application.
Differences of serum total protein, albumin level between two groups before and after tourniqutte application.
Interventional
Parallel
Randomized
Individual
Single blind -participants are blinded
No treatment
NO
NO
Institution is not considered as adjustment factor.
NO
Numbered container method
2
Prevention
Medicine |
Before combined spinal anesthesia, the patients allocated in group HES, received intravenously 6% hydroxyethyl starch solution 10ml/kg(body weight).
Before combined spinal epidural anesthesia, the patients allocated in group NS, received intravenously normal saline 10ml/kg(body weight).
65 | years-old | <= |
80 | years-old | >= |
Male and Female
scheduled total knee arthroplaty
unilateral
under combined epidural-spinal anesthesia
emergency surgery
uncontrolled hypertension, diabetes
ASA class III, IV
60
1st name | |
Middle name | |
Last name | JAE HO LEE |
National Health Institution Ilsan Hospital
Department of Anesthesiology and Pain Medicine
1232, Baekseok-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do, Korea
82319000298
lijhmd71@hotmail.com
1st name | |
Middle name | |
Last name | JAE HO LEE |
National Health Institution Ilsan Hospital
Department of Anesthesiology and Pain Medicine
1232, Baekseok-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do, Korea
82319000298
lijhmd71@hotmail.com
National Health Insurance Corporation Ilsan Hospital
National Health Insurance Corporation Ilsan Hospital
Outside Japan
NO
2016 | Year | 05 | Month | 20 | Day |
Unpublished
Enrolling by invitation
2016 | Year | 05 | Month | 04 | Day |
2016 | Year | 05 | Month | 17 | Day |
2016 | Year | 05 | Month | 20 | Day |
2016 | Year | 05 | Month | 24 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000025791
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