Unique ID issued by UMIN | UMIN000022458 |
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Receipt number | R000025846 |
Scientific Title | PET study on change of neurotransmitter release induced by exercise |
Date of disclosure of the study information | 2016/05/25 |
Last modified on | 2019/04/02 20:30:10 |
PET study on change of neurotransmitter release induced by exercise
Exercise PET on neurotransmitter release
PET study on change of neurotransmitter release induced by exercise
Exercise PET on neurotransmitter release
Japan |
healthy volunteers
Adult |
Others
NO
In the present study, we measure with positron emission tomography (PET) neuroreceptor density in the brain of healhty volunteers during the exercise and in the resting condition. We plan to evaluate the intrabrain release change in dopamin and histamine. IN addition, we plan to measure subjective such as fatigue, frank, quality of life (QOL) and cognitive functions, using questionnaires and computer test. All data will be examined to see correlations among factors.
Pharmacokinetics
Exploratory
Others
Not applicable
*binding potential values that is reflecting receptor density for dopamin D2 receptor (11C-raclopride)
*binding potential values that is reflecting receptor density for histamine receptor (11C-doxepin)
*subjective feeling such as fatigue and frank measured with POMS as well as quality of life (QOL)
*autonomic nervous function
*blood chemistry (endocrine and immue)
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
NO
NO
Institution is not considered as adjustment factor.
NO
No need to know
1
Treatment
Medicine | Behavior,custom |
Exercise load with an ergometer bicycle continuing up to 50 min (VO2max 55%). PET scanning starts during the exercise loading and pharmacokinetic information of 11C-raclopride (dopamin D2 receptor) measurement is done. The results are compared to those obtained under resting state.
20 | years-old | <= |
30 | years-old | >= |
Male
(1) right handed men with a habit of regular exercise of 1 or 2 days a week
(2) those who were judged as suitable for the current study by physical strength tests
(1) abnormality of brain structure shown by MRI
(2) any cardiac problems such as arrhythmia
(3) severe allergy
(4) regular administration of any therapeutic drugs
20
1st name | Manabu |
Middle name | |
Last name | Tashiro |
Tohoku University Cyclotron and Radioisotope Center
Div. of Cyclotron Nuclear Medicine
980-8578
6-3 AzaAoba Aramaki Aoba-ku Sendai-shi Myagi-ken 980-8578 Japan
022-795-7797
mtashiro@m.tohoku.ac.jp
1st name | Kazuko |
Middle name | |
Last name | Takeda |
Cyclotron and Radioisotope Center, Tohoku Univeristy
Div. of Cyclotron Nuclear Medicine
980-8578
6-3 AzaAoba Aramaki Aoba-ku Sendai-shi Myagi-ken 980-8578 Japan
022-795-4438
driving@cyric.tohoku.ac.jp
Tohoku University
Society for the promotion of science
Japanese Governmental office
Japan
University of Electro-Communications
Ethics comittee of Graduate School of Medicine, Tohoku University
1-1 Seiryocho Aoba-ku Sendai-shi Miyagi-ken
0227178007
med-kenkyo@grp.tohoku.ac.jp
YES
2011-621
Clinical research ethics comittee of Tohoku University Hospital
東北大学サイクロトロン・RIセンター
2016 | Year | 05 | Month | 25 | Day |
Unpublished
17
[11C]racloprinde PET measurements were done in Japanese young healthy volunteers in resting and exercise loading conditions. In comparison to resting condition, significantly better performance was observed in exercise loading condition. And increased dopamine release in the brain was also observed in PET images.
2019 | Year | 04 | Month | 02 | Day |
Completed
2016 | Year | 05 | Month | 25 | Day |
2016 | Year | 05 | Month | 18 | Day |
2016 | Year | 05 | Month | 25 | Day |
2018 | Year | 12 | Month | 19 | Day |
2018 | Year | 12 | Month | 19 | Day |
2019 | Year | 02 | Month | 28 | Day |
2019 | Year | 03 | Month | 20 | Day |
2016 | Year | 05 | Month | 25 | Day |
2019 | Year | 04 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000025846
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