Unique ID issued by UMIN | UMIN000022657 |
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Receipt number | R000026115 |
Scientific Title | The ACTH stimulation test and computed tomography are useful for determining the subtype of primary aldosteronis m |
Date of disclosure of the study information | 2016/06/08 |
Last modified on | 2016/06/08 10:55:31 |
The ACTH stimulation test and computed tomography are useful for determining the subtype of primary aldosteronis m
Useful test and value for determining the subtype of primary aldosteronism
The ACTH stimulation test and computed tomography are useful for determining the subtype of primary aldosteronis m
Useful test and value for determining the subtype of primary aldosteronism
Japan |
Primary aldosteronism
Endocrinology and Metabolism |
Others
NO
The diagnostic steps for primary aldosteronism (PA) include case screening tests, confirmatory tests, and localization. The aim of this study was to investigate useful confirmatory tests and their cut-off values for determining the subtype of primary aldosteronism, especially in unilateral PA, such as aldosterone-producing adenoma, and bilateral PA, such as idiopathic hyperaldosteronism.
Others
Adrenal venous sampling (AVS) is the gold-standard test to differentiate unilateral from bilateral disease. However, AVS is far from easy to perform for all patients with PA because of some problems.Therefore, bilateral cases of patients with PA should be identified in a minimally invasive manner before performing AVS.
Investigation of usefulness confirmatory test and
value for determining the subtype of primary aldosteronism
Observational
Not applicable |
Not applicable |
Male and Female
The medical records of patients diagnosed with PA by confirmatory testing and localization by AVS were retrospectively analyzed. Ninety patients admitted to Nippon Medical School Hospital for AVS from January 2009 to March 2015 were examined. The diagnosis was confirmed by endocrinological examinations such as confirmatory tests (CCT, FUT and SIT) and ACTH-stimulated AVS (ACTH-AVS).
A patient who had iodine allergy and used steroid during AVS
Five patients who were diagnosed with subclinical Cushing's syndrome
Four patients taking antihypertensive drugs other than calcium channel blockers and a blockers for refractory hypertension
One patient with suspected bilateral aldosterone producing adenomas
Two patients with unsuccessful AVS
One patient who had aldosterone excess and LR over 2.6 on AVS, but CR was over 1.0
76
1st name | |
Middle name | |
Last name | Hitoshi Sugihara |
Graduate School of Medicine, Nippon Medical School
Department of Endocrinology, Diabetes and Metabolism
1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan
03-3822-2131
hitoshi@nms.ac.jp
1st name | |
Middle name | |
Last name | AYAKO MORIYA |
Graduate School of Medicine, Nippon Medical School
Department of Endocrinology, Diabetes and Metabolism
1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan
03-3822-2131
ayako0414@nms.ac.jp
Graduate School of Medicine, Nippon Medical School
Graduate School of Medicine, Nippon Medical School
Other
NO
2016 | Year | 06 | Month | 08 | Day |
Unpublished
Completed
2009 | Year | 01 | Month | 01 | Day |
2009 | Year | 01 | Month | 01 | Day |
retrospective review
2016 | Year | 06 | Month | 08 | Day |
2016 | Year | 06 | Month | 08 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026115
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