Unique ID issued by UMIN | UMIN000022815 |
---|---|
Receipt number | R000026294 |
Scientific Title | A longitudinal study of the fluvoxamine treatment for the structural and functional connectivity between the orbitofrontal cortex and the ventral striatum in obsessive compulsive disorder |
Date of disclosure of the study information | 2016/09/01 |
Last modified on | 2021/06/24 14:10:31 |
A longitudinal study of the fluvoxamine treatment for the structural and functional connectivity between the orbitofrontal cortex and the ventral striatum in obsessive compulsive disorder
A longitudinal study of the fluvoxamine treatment for the structural and functional connectivity between the orbitofrontal cortex and the ventral striatum in obsessive compulsive disorder
A longitudinal study of the fluvoxamine treatment for the structural and functional connectivity between the orbitofrontal cortex and the ventral striatum in obsessive compulsive disorder
A longitudinal study of the fluvoxamine treatment for the structural and functional connectivity between the orbitofrontal cortex and the ventral striatum in obsessive compulsive disorder
Japan |
obsessive-compulsive disorder
Psychiatry | Adult |
Others
NO
To reveal the neural basis of the obsessive-compulsive disorder applying neuroimaging studies, psychological tests and blood examinations
Others
In the study using mice, repeated stimulation of the orbitofrontal cortex (OFC)-the ventral striatum (VS) projections using optogenetics was reported to increase the firing of postsynaptic VS cells and the frequency of over grooming behavior, which represents obsessive-compulsive symptoms in mice. We have detected the hyper functional and structural connectivities between OFC and VS through the neuroimaging studies of patients with obsessive-compulsive disorder (OCD). Other group reported that this hyper functional connectivity was repaired with deep brain stimulation, while there are no reports with other treatments Thus, in the present study we reveal how these hyper connectivities change with the fluvoxamine that is generally recommended drug to treat OCD in Japan.
The strength of the functional and structural connectivity between the orbitofrontal cortex and the ventral striatum evaluated 12 weeks after starting fluvoxamines
Interventional
Parallel
Non-randomized
Open -but assessor(s) are blinded
Active
2
Treatment
Medicine |
Patients with obsessive-compulsive disorder treated with fluvoxamine. The initial daily dose is 50 mg and gradually increased up to 300 mg given in 2 divided doses.
healthy volunteers
20 | years-old | <= |
Not applicable |
Male and Female
The inclusion criteria for patients were: (1) patients with obsessive compulsive disorder treated at the Kyoto Prefectural University of Medicine Hospital, Kyoto, Japan; (2) not having current or past diagnosis of psychiatric diseases and significant physical disease except the major depressive disorder; (3) the ability to give written, informed consent after receiving a complete description of the study.
The inclusion criteria for healthy controls were: (1) healthy controls matched for age and sex participated in this study without current or past diagnosis of psychiatric diseases and significant physical disease except the major depressive disorder: (2) the ability to give written, informed consent after receiving a complete description of the study.
The exclusion criteria for patients and healthy controls were: (1) cardiac pacemakers or other metallic implants or artifacts; (2) other factors.
30
1st name | Takashi |
Middle name | |
Last name | Nakamae |
Graduate School of Medical Science,
Kyoto Prefectural University of Medicine,
Department of Psychiatry
602-8566
465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
075-251-5612
nakamae@koto.kpu-m.ac.jp
1st name | Takashi |
Middle name | |
Last name | Nakamae |
Graduate School of Medical Science, Kyoto Prefectural University of Medicine,
Department of Psychiatry
602-8566
465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
075-251-5612
nakamae@koto.kpu-m.ac.jp
Department of Psychiatry,
Graduate School of Medical Science,
Kyoto Prefectural University of Medicine,
Japan Science and Technology Agency
Japanese Governmental office
The Medical Committee on Human Studies at the Kyoto Prefectural University of Medicine
465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
075-251-5337
rinri@koto.kpu-m.ac.jp
NO
京都府立医科大学附属病院精神科・心療内科
2016 | Year | 09 | Month | 01 | Day |
Unpublished
Open public recruiting
2016 | Year | 09 | Month | 01 | Day |
2017 | Year | 01 | Month | 05 | Day |
2016 | Year | 09 | Month | 01 | Day |
2023 | Year | 06 | Month | 23 | Day |
2016 | Year | 06 | Month | 21 | Day |
2021 | Year | 06 | Month | 24 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026294
Research Plan | |
---|---|
Registered date | File name |
2018/12/26 | 研究計画書_フルボキサミン縦断研究20181126.docx |
Research case data specifications | |
---|---|
Registered date | File name |
Research case data | |
---|---|
Registered date | File name |