Unique ID issued by UMIN | UMIN000022850 |
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Receipt number | R000026336 |
Scientific Title | Estimation of 10B concentration in boron neutron capture therapy: potential of image-guided therapy using 18FBPA PET |
Date of disclosure of the study information | 2016/06/30 |
Last modified on | 2016/06/23 10:23:54 |
Estimation of 10B concentration in boron neutron capture therapy: potential of image-guided therapy using 18FBPA PET
Normal 10B concentration and 18FBPA PET
Estimation of 10B concentration in boron neutron capture therapy: potential of image-guided therapy using 18FBPA PET
Normal 10B concentration and 18FBPA PET
Japan |
Normal volunteer
Adult |
Others
NO
In boron neutron capture therapy (BNCT) for cancer, the accurate estimation of 10B tissue concentrations, especially in neighboring normal organs, is important to avoid adverse effects. The 10B concentration in normal organs after loading with 10B, however, has not been established in humans. In this study, we performed 4-borono-2-[18F]-fluoro-phenylalanine (18FBPA) PET in healthy volunteers and estimated the chronological changes in the 10B concentrations of normal organs.
Pharmacokinetics
Not applicable
Estimation of 10B concentration in normal organs using 18FBPA PET.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Maneuver |
Venous cannulation and injection of radioisotope.
20 | years-old | <= |
70 | years-old | >= |
Male and Female
Normal volunteers aged from 20 years-old to 70 years-old.
1. a pregnant woman and a subject nursing or person in hope of the pregnancy.
2. Person younger than 20 year.
3. in addition, the person who judged that it was inappropriate.
6
1st name | |
Middle name | |
Last name | Jun Hatazawa |
Osaka University Graduate School of Medicine
Department of Nuclear Medicine and Tracer Kinetics
2-2 Yamadaoka, Suita, Osaka
06-6879-3461
hatazawa@tracer.med.osaka-u.ac.jp
1st name | |
Middle name | |
Last name | Eku Shimosegawa |
Osaka University Graduate School of Medicine
Department of Molecular Imaging in Medicine
2-2 Yamadaoka, Suita, Osaka
06-6879-3767
eku@mi.med.osaka-u.ac.jp
Osaka University Graduate School of Medicine
The Ministry of Education, Culture, Sports, Science and Technology, Japan.
Japanese Governmental office
NO
2016 | Year | 06 | Month | 30 | Day |
Unpublished
Completed
2013 | Year | 06 | Month | 01 | Day |
2013 | Year | 07 | Month | 08 | Day |
2016 | Year | 06 | Month | 23 | Day |
2016 | Year | 06 | Month | 23 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026336
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