Unique ID issued by UMIN | UMIN000022859 |
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Receipt number | R000026340 |
Scientific Title | Evaluation of the correlation between serum carnitine and constipation |
Date of disclosure of the study information | 2016/06/25 |
Last modified on | 2017/07/18 18:20:17 |
Evaluation of the correlation between serum carnitine and constipation
Evaluation of the correlation between serum carnitine and constipation
Evaluation of the correlation between serum carnitine and constipation
Evaluation of the correlation between serum carnitine and constipation
Japan |
carnitine defeciensy,
constipatin\on
Medicine in general | Gastroenterology |
Others
NO
Carnitine, which is acquired mostly through the diet, is an essential nutrient related to the mitochondrial transport of fatty acids. Carnitine deficiency causes a variety of symptoms in multiple organs due to mitochondrial dysfunction.
Most patients with severe motor and intellectual disabilities have epilepsy and are prescribed anti-epileptic drugs such as valproate sodium, which promotes the excretion of carnitine. Furthermore, as most of these patients cannot feed themselves, they receive enteral nutrition, which has less carnitine content than a normal diet. Use of valproate sodium and most enteral nutrition formulas for an extended time has been reported as a risk factor for carnitine deficiency. Therefore, patients with severe motor and intellectual disabilities are known to be at risk of deficiency of carnitine.
In our clinical practice we have treated many patients with severe motor and intellectual disabilities who have experienced relief from constipation after supplementation of carnitine. However, to our knowledge, there are few reports of studies designed to examine correlations between gastrointestinal dysmotility and deficiency of carnitine. Therefore, this study aimed to retrospectively review clinical data of patients with severe motor and intellectual disabilities in order to assess our suspicion of a correlation between constipation and carnitine deficiency.
Efficacy
Confirmatory
First, we examined the correlation between level of free carnitine and severity of constipation.
Second, we compared the constipation group with the non-constipation group in terms of age, sex, BMI, bed rest period (years), use of anti-epileptic drugs, use of valproate sodium, use of enteral nutrition, recurrent pulmonary infection (more than twice a year), presence of pressure ulcer, and results of blood tests for nutritional assessment (including serum levels of albumin, pre-albumin, total cholesterol, free carnitine, folic acid, and the trace elements Cu, Fe, Se, and Zn). Blood samples were collected in all cases during times when there were no observed inflammation reactions and no prescribed antibiotics. Carnitine levels also were obtained from patients without motor and intellectual disabilities who had severe chronic constipation requiring disimpaction with an enema on a daily basis.
Third, we compared the frequency of defecation and the form of feces before and after therapeutic supplementation with carnitine.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Treatment
Medicine |
Supplementation with 10-50 mg/kg/day carnitine (P<0.001). No other changes of medication were made during the supplementation period.
2 | years-old | <= |
45 | years-old | >= |
Male and Female
Patients with severe motor and intellectual disabilities were defined as having an inability to move by themselves and IQ <35
The patients with infection or prescribed with antibiotics
27
1st name | |
Middle name | |
Last name | Shinya Murata |
Hirakata City Hospital,
Department of Pediatrics,
2-14-1 Kinya-honmachi, Hirakata, Osaka 573-1013, Japan
072-847-2821
wildwind1980@live.jp
1st name | |
Middle name | |
Last name | Shinya Murata |
Hirakata City Hospital,
Department of Pediatrics,
2-14-1 Kinya-honmachi, Hirakata, Osaka 573-1013, Japan
072-847-2821
wildwind1980@live.jp
Department of Pediatrics, Hirakata City Hospital
Department of Pediatrics, Hirakata City Hospital
Local Government
NO
2016 | Year | 06 | Month | 25 | Day |
Published
Completed
2015 | Year | 01 | Month | 01 | Day |
2015 | Year | 01 | Month | 01 | Day |
2016 | Year | 06 | Month | 23 | Day |
2017 | Year | 07 | Month | 18 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026340
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