Unique ID issued by UMIN | UMIN000023198 |
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Receipt number | R000026690 |
Scientific Title | Imaging and epigenetic study for the therapeutic mechanism of ECT in the treatment of referactory depression |
Date of disclosure of the study information | 2016/07/25 |
Last modified on | 2016/07/16 15:01:14 |
Imaging and epigenetic study for the therapeutic mechanism of ECT in the treatment of referactory depression
Imaging and epigenetic study of ECT
Imaging and epigenetic study for the therapeutic mechanism of ECT in the treatment of referactory depression
Imaging and epigenetic study of ECT
Japan |
Refractory depression
Psychiatry |
Others
NO
To elucidate the therapeutic mechanism of ECT in the treatment of refractory depressin using functional connectivity measured by fMRI and DNA methylation.
Others
To develop the prognostic biomarker in the treatment of feractory depressin in response to ECT
Exploratory
Explanatory
Not applicable
Hamilton rating scale for depression
Functinal connectivity analysis
DNA methylation
Outcome measurement is done 1 day and 3 months after the final ECT.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
NO
NO
Institution is not considered as adjustment factor.
NO
No need to know
1
Treatment
Device,equipment |
Electoric convulsive therapy
(Twice/week, Total 10 times, Duration 5 weeks)
20 | years-old | <= |
Not applicable |
Male and Female
Patients with major depression diagnosed by DSM-V and MINI. They did not respond to appropriate antidepressant treatments.
Patients with major depression and other psychiatric disorders.
Patients with major organic brain disorders.
Patients who did not met ECT criteria due to physical illness.
20
1st name | |
Middle name | |
Last name | Shigeru Morinobu |
Kochi University
Dept. neuropsychiatry, Med. Sch.
Kohasu, Oko-cho, Nankoku, Kochi
088-880-2359
smorinob@kochi-u.ac.jp
1st name | |
Middle name | |
Last name | Shigeru Morinobu |
Kochi University
Dept. Neuropsychiatry, Med. Sch.
Kohasu, Oko-cho, Nankoku, Kochi
088-880-2359
https://kochi.neuropsychiatry/
smorinob@kochi-u.ac.jp
Department of Neuropsychiatry, Kochi Medical School, Kochi University
Department of Neuropsychiatry, Kochi Medical School, Kochi University
Japanese Governmental office
Japan
Kochi University of Technology
No
NO
高知大学病院(高知県)、高知工科大学(高知県)
2016 | Year | 07 | Month | 25 | Day |
Unpublished
Enrolling by invitation
2013 | Year | 06 | Month | 09 | Day |
2013 | Year | 10 | Month | 01 | Day |
2016 | Year | 07 | Month | 16 | Day |
2016 | Year | 07 | Month | 16 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026690
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