Unique ID issued by UMIN | UMIN000023296 |
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Receipt number | R000026844 |
Scientific Title | Organized Registration for the Assessment of dementia for Nationwide General consortium toward Effective treatments in Japan: ORANGE - Preclinical AD |
Date of disclosure of the study information | 2016/07/23 |
Last modified on | 2021/01/28 17:04:43 |
Organized Registration for the Assessment of dementia for Nationwide
General consortium toward Effective treatments in Japan: ORANGE - Preclinical AD
ORANGE - Preclinical AD study
Organized Registration for the Assessment of dementia for Nationwide
General consortium toward Effective treatments in Japan: ORANGE - Preclinical AD
ORANGE - Preclinical AD study
Japan |
Healthy elderly adults with poor cognitive performance
Medicine in general | Neurology | Geriatrics |
Psychiatry | Adult |
Others
YES
The ORANGE studies are aimed at establishing an organized and dynamic registration system that collects time-based information based on age and disease stages (the ORANGE platform) by monitoring the entire clinical course of patients with dementia, including Alzheimer's Disease (AD).
Others
The aim of ORANGE-Preclinical AD (cohort study) is to construct a registration system that collects information of healthy and preclinical participants, which contributes to the promotion of preventive research against dementia incidence.
Others
Others
Not applicable
Survival analysis is performed to determine the consequence of mild cognitive impairment (MCI) and dementia diagnoses. Other methods are added in order to search for an optimal statistical method.
To determine the reliability and validity of the system to assess the relationships among cognitive ability examination, MCI detection, lifestyle, and the types of clinic information in healthy elderly individuals. In addition, to use the results of the prospective study to determine the reliability and validity of the preclinical AD or MCI, which is obtained from the system, thereby, accelerating the process of MCI registry.
Observational
65 | years-old | <= |
Not applicable |
Male and Female
1) Elderly adults who have participated
in cohort studies, 2) Native speaker who is healthy, preclinical, and with mild cognitive impairment (MCI), 3) Mini-mental state examination (MMSE) score 24 and over, 4) participants who sign the approved informed written consent form, 5) no limitations on age, sex, and medications.
1) MCI, dementia with Lewy bodies,
frontotemporal lobe dementia, Parkinson's disease, stroke, Huntington's disease, normal-pressure hydrocephalus, brain tumors, progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy, epilepsy, subdural hematoma, encephalitis / meningitis, multiple sclerosis, and brain injury with decline cognitive, 2) any local lesion such as cerebral infarction(s) detected by computed tomography (CT) or magnetic resonance imaging (MRI) before enrollment that can greatly affect cognitive function, 3) history of major depression, bipolar disorder, schizophrenia, and alcohol/drug abuse; and current serious or unstable disease, 4) inability to undergo cognitive tests, 5) patients deemed ineligible for enrollment by the lead principal investigator or co-researcher at each institution.
13350
1st name | Hiroyuki |
Middle name | |
Last name | Shimada |
National Center for Geriatrics and Gerontology
Department of Preventive Gerontology
474-8511
7-430 Morioka-cho, Obu City, Aichi Prefecture
0562-44-5651
shimada@ncgg.go.jp
1st name | Sangyoon |
Middle name | |
Last name | Lee |
National Center for Geriatrics and Gerontology
Section of Cohort Study for Longevity, Department of Preventive Gerontology
474-8511
7-430 Morioka-cho, Obu City, Aichi Prefecture
0562-45-5638
sylee@ncgg.go.jp
National Center for Geriatrics and Gerontology
Japan Agency for Medical Research and Development (AMED)
Japanese Governmental office
Japan
National Center for Geriatrics and Gerontology
7-430 Morioka-cho, Obu City, Aichi Prefecture
0562-44-5651
yaday@ncgg.go.jp
NO
国立研究開発法人国立長寿医療研究センター
2016 | Year | 07 | Month | 23 | Day |
Unpublished
Enrolling by invitation
2015 | Year | 11 | Month | 02 | Day |
2016 | Year | 07 | Month | 22 | Day |
The ORANGE studies are aimed at establishing an organized and dynamic registration system that collects time-based information based on age and disease stages (the ORANGE platform) by monitoring the entire clinical course of patients with dementia, including Alzheimer's Disease (AD).The aim of ORANGE-Preclinical AD (cohort study) is to construct a registration system that collects information of healthy and preclinical participants, which contributes to the promotion of preventive research against dementia incidence.
2016 | Year | 07 | Month | 22 | Day |
2021 | Year | 01 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026844
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