Unique ID issued by UMIN | UMIN000023483 |
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Receipt number | R000027050 |
Scientific Title | Efficacy and safety of PCSK9 inhibitor for dyslipidemia |
Date of disclosure of the study information | 2016/08/04 |
Last modified on | 2021/02/06 09:32:58 |
Efficacy and safety of PCSK9 inhibitor for dyslipidemia
EVOLUTION trial (effects of EVOLocUmab on lipid and oxidaTIve stress biOmarkers in high-risk patieNts with Cardiovascular disease)
Efficacy and safety of PCSK9 inhibitor for dyslipidemia
EVOLUTION trial (effects of EVOLocUmab on lipid and oxidaTIve stress biOmarkers in high-risk patieNts with Cardiovascular disease)
Japan |
refractory dyslipidemia
Endocrinology and Metabolism |
Others
NO
To investigate the efficacy and safety of PCSK9 inhibitor (Evolocumab).
Safety,Efficacy
LDL, HDL, T-cho(Pre, 1M, 3M, 6M, 1Y, 2Y)
Pre, 6M, 1Y, 2Y
1) FMD
2) carotis echo
3) ABI
Pre, 3M, 6M, 1Y, 2Y
4) U-alb, U-type IV collagen
5) cystatin C, ox-LDL, Lp (a), EPA/AA, Apo A1, B, E, TG
6) Cr,eGFR
7) complications
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
PCSK9 inhibitor (repasa) for patients with refractory dyslipidemia
140mg/every 2 weeks for 24 months
20 | years-old | <= |
90 | years-old | >= |
Male and Female
refractory dyslipidemia
Doctor's decision not to register to this regimen
70
1st name | Akira |
Middle name | |
Last name | Sezai |
Nihon University School of medicine
Department of Cardiovascular Surgery
1738610
30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan
03-3982-8111
asezai.med@gmail.com
1st name | Akira |
Middle name | |
Last name | Sezai |
Nihon University School of Medicine
Department of Cardiovascular Surgery
1738610
30-1 Oyaguchi kami-machi, Itabashi-ku, Tokyo, Japan
03-3982-8111
asezai.med@gmail.com
Sekino Hospital
Self funding
Self funding
Sekino Laboratory
3-28-3 ikebukuro, Toshima-ku, Tokyo, Japan
03-3986-5501
skn-np@sekino-hospital.com
NO
関野病院(東京都)
2016 | Year | 08 | Month | 04 | Day |
Unpublished
Completed
2016 | Year | 06 | Month | 01 | Day |
2016 | Year | 10 | Month | 10 | Day |
2016 | Year | 10 | Month | 15 | Day |
2020 | Year | 12 | Month | 31 | Day |
2016 | Year | 08 | Month | 04 | Day |
2021 | Year | 02 | Month | 06 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000027050
Research Plan | |
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Registered date | File name |
2017/04/27 | 研究計画書.docx |
Research case data specifications | |
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Registered date | File name |
Research case data | |
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Registered date | File name |