Unique ID issued by UMIN | UMIN000023797 |
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Receipt number | R000027419 |
Scientific Title | Study on susceptibility genes for SMON |
Date of disclosure of the study information | 2017/12/01 |
Last modified on | 2016/08/28 14:26:38 |
Study on susceptibility genes for SMON
Study on susceptibility genes for SMON
Study on susceptibility genes for SMON
Study on susceptibility genes for SMON
Japan |
SMON(subacute myelo-optico-neuropathy)
Neurology |
Others
YES
We will analyze a NQO1 polymorphism (C609T)which may affect toxicity of clioquinol and compare its allele frequencies between SMON and non-SMON Japanese populations.
Others
SMON was a drug disaster caused by clioquinol. NQO1 is an oxidoreductase which is expressed widely in human tissues and may importantfor reduction of clioquinol toxicity. Japanese has high frequency of "loss of function" allele of NQO1 (609T). SMON was prevalent in Japan even clioquinol was used in the world. We hypothesized that this "loss of function allele of C609T polymorphism is much more prevalent in SMON population than healthy Japanese population. If so, this may be explained why SMON was much more frequent in Japan than other countries.
Others
Others
Not applicable
Allele frequency of C609T of NQO1 gene
Observational
Not applicable |
Not applicable |
Male and Female
Diagnosed as having SMON
Non-SMON
100
1st name | |
Middle name | |
Last name | Toshiyuki Fukao |
Graduate school of medicine, Gifu University
Department of Pediatrics
Yanagido 1-1, Gifu
058-230-6380
toshi-gif@umin.net
1st name | |
Middle name | |
Last name | Toshiyuki Fukao |
Graduate school of medicine, Gifu University
Department of Pediatrics
Yanagido 1-1, Gifu
058-230-6380
toshi-gif@umin.net
Gifu University
the Ministry of Health, Labor and Welfare of Japan
Japanese Governmental office
NO
2017 | Year | 12 | Month | 01 | Day |
Unpublished
No longer recruiting
2016 | Year | 07 | Month | 27 | Day |
2016 | Year | 09 | Month | 01 | Day |
None
2016 | Year | 08 | Month | 28 | Day |
2016 | Year | 08 | Month | 28 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000027419
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