Unique ID issued by UMIN | UMIN000024555 |
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Receipt number | R000028233 |
Scientific Title | Novel approach to coronary artery disease through the gut microbiota and its metabolite |
Date of disclosure of the study information | 2017/01/01 |
Last modified on | 2017/02/09 09:03:22 |
Novel approach to coronary artery disease through the gut microbiota and its metabolite
Prevention and treatment of coronary artery disease through the gut
Novel approach to coronary artery disease through the gut microbiota and its metabolite
Prevention and treatment of coronary artery disease through the gut
Japan |
coronary artery disease
Cardiology | Adult |
Others
NO
To clarify the characterization of gut microbial metabolites in the patients with coronary artery disease.
And to clarify prebiotics and probiotics which can prevent or treat coronary artery disease.
Safety,Efficacy
To elucidate the gut microbiota and its metabolites in feces after co-culture with prebioticas or probiotics in Kobe University Human Intestinal Model (KUHIM).
The difference of the gut microbiota and its metabolites in feces after co-culture with prebioticas or probiotics in KUHIM between coronary artery disease patients and control patients.
Observational
20 | years-old | <= |
100 | years-old | >= |
Male and Female
Coronary artery disease group
=patients diagnosed as coronary artery disease
Control group
=patients who have coronary risk factors such as hypertension, dyslipidemia, and/or diabetes, but who do not have coronary artery disease.
1) serum creatinine of greater than or equal to 3.0 mg/dL
2) patients with NYHA of greater than or equal to 3
3) patients with malignancy
4) patients with autoimmune disease or chronic inflammatory state
5) patients with inflammatory bowel diseases or intestinal surgery
6) BMI of more than 30kg/m2 or less than 15kg/m2
7) patients with low left ventricular ejection fraction (LVEF < 45%)
90
1st name | |
Middle name | |
Last name | Ken-ichi Hirata |
Kobe University Graduate School of Medicine
Division of Cardiovascular Medicine, Department of Internal Medicine
7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 6500017, Japan
078-382-5111
hiratak@med.kobe-u.ac.jp
1st name | |
Middle name | |
Last name | Tomoya Yamashita |
Kobe University Graduate School of Medicine
Division of Cardiovascular Medicine, Department of Internal Medicine
7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 6500017, Japan
078-382-5111
tomoya@med.kobe-u.ac.jp
Division of Cardiovascular Medicine, Department of Internal Medicine,
Kobe University Graduate School of Medicine
Division of Cardiovascular Medicine, Department of Internal Medicine,
Kobe University Graduate School of Medicine
Self funding
Kobe university graduated school of science, technology, and innovation
NO
2017 | Year | 01 | Month | 01 | Day |
Unpublished
Enrolling by invitation
2016 | Year | 11 | Month | 01 | Day |
2017 | Year | 02 | Month | 01 | Day |
We co-culture feces of coronary artery disease patietns with various prebiotics/probiotics in Kobe University Human Intestinal Model. The purpose of this study is to identify the prebiotics/probiotics which can lead gut microbiota and its metabolites considered to be cardiovascular protective.
2016 | Year | 10 | Month | 25 | Day |
2017 | Year | 02 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028233
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