Unique ID issued by UMIN | UMIN000024565 |
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Receipt number | R000028264 |
Scientific Title | Plasma orexin level in patients with delirium |
Date of disclosure of the study information | 2016/10/26 |
Last modified on | 2019/04/30 17:20:00 |
Plasma orexin level in patients with delirium
Plasma orexin level in patients with delirium
Plasma orexin level in patients with delirium
Plasma orexin level in patients with delirium
Japan |
delirium
Geriatrics | Psychiatry |
Others
NO
To assess the difference in plasma orexin concentration between patients with and without delirium.
Others
This study do not perform any pharmacological nor non-pharmacological interventions.
Confirmatory
Explanatory
Not applicable
Difference in plasma orexin concentration between patients with and without delirium on the two to four hospital day.
1. Difference in plasma orexin concentration between on early hospital day (day 2 to 4) and on later hospital day (day 10 to 12) in patients with delirium on the early hospital day.
2. Difference in plasma orexin concentration between on early hospital day (day 2 to 4) and on later hospital day (day 10 to 12) in patients without delirium on the early hospital day.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Maneuver |
Obtain 10 mL of blood by venous puncture.
Two time per patient. The first time is on 2nd-4th hospital day, and the second time is 10th-12th hospital day.
65 | years-old | < |
Not applicable |
Male and Female
All inpatients in the geriatric ward in the Nagoya University Hospital.
1. Patients taking suvorexant (antagonist of orexin receptors).
2. Patients planned to discharge before the 10th hospital day.
70
1st name | Hirotaka |
Middle name | |
Last name | Nakashima |
Nagoya University Hospital
Centre for Community Liaison and Patient Consultation
466-8560
65 Tsurumai-cho, Showa-ku, Nagoya, Japan
052-744-1920
naka621@med.nagoya-u.ac.jp
1st name | Hirotaka |
Middle name | |
Last name | Nakashima |
Nagoya University Hospital
Centre for Community Liaison and Patient Consultation
466-8560
65 Tsurumai-cho, Showa-ku, Nagoya, Japan
052-744-1920
naka621@med.nagoya-u.ac.jp
Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine
Ministry of education
Japanese Governmental office
the Ethics Committee of Nagoya University Graduate School of Medicine
65 Tsurumai-cho, Showa-ku, Nagoya, Japan
052-741-2111
ethics@med.nagoya-u.ac.jp
NO
名古屋大学医学部附属病院(愛知県)
2016 | Year | 10 | Month | 26 | Day |
https://onlinelibrary.wiley.com/doi/full/10.1111/psyg.12444
Published
https://onlinelibrary.wiley.com/doi/full/10.1111/psyg.12444
70
Among the 70 patients, 15 (21.4%) was diagnosed as delirium.
There was no significant difference in the levels of orexin-A between patients with and without delirium. Orexin-A levels had no association with delirium severity or delirium subtype. Also, there was no difference in orexin-A levels in patients with delirium before and after amelioration.
Additional analyses revealed that plasma orexin-A levels were negatively correlated with renal function (eGFR and creatinine clearance).
2019 | Year | 04 | Month | 30 | Day |
2019 | Year | 03 | Month | 19 | Day |
84.8 years old on average. Male 35 (50%).
On hospital days 2-4, fasting blood was collected in the morning. Delirium was also evaluated at the same time.
none
Plasma orexin-A level. Delirium on hospital days 2-4. Severity and subtype of delirium. Renal function (eGFR, reatinine clearance)
Completed
2017 | Year | 09 | Month | 15 | Day |
2017 | Year | 09 | Month | 15 | Day |
2017 | Year | 10 | Month | 01 | Day |
2018 | Year | 02 | Month | 07 | Day |
2018 | Year | 06 | Month | 30 | Day |
2018 | Year | 06 | Month | 30 | Day |
2018 | Year | 08 | Month | 31 | Day |
Patient recruitment: Hospitalized patients in the geriatric ward in the Nagoya University Hospital who fulfill the inclusion criteria
Recruitment period: From the day the Ethics Committee approves the study to March 31, 2018
2016 | Year | 10 | Month | 26 | Day |
2019 | Year | 04 | Month | 30 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028264
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