Unique ID issued by UMIN | UMIN000025307 |
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Receipt number | R000028386 |
Scientific Title | Identification of biomarkers for diagnosis of major depression |
Date of disclosure of the study information | 2017/01/01 |
Last modified on | 2022/12/22 09:36:48 |
Identification of biomarkers for diagnosis of major depression
Identification of biomarkers of depression
Identification of biomarkers for diagnosis of major depression
Identification of biomarkers of depression
Japan |
Major depressive disorder
Psychiatry |
Others
NO
Examining the effect of exercise therapy on depression and salivary levels of cortisol, alpha-amylase, and cytokines.
Efficacy
Hamilton depression rating scale, Montgomery-Asberg Depression Rating Scale, and salivary levels of cortisol, alpha-amylase, and cytokines.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Behavior,custom |
Eight weeks of exercise therapy
20 | years-old | <= |
Not applicable |
Male and Female
Major depression group:
Adults diagnosed as major depressive disorder
Control group:
Adults not diagnosed as major depressive disorder
1. Suffers from any inflammatory, endocrine, or metabolic disorders or suffers from severe periodontal disease.
2. Has taken anti-allergic medication, steroid, or immunosuppressant medication in the past month.
3. Suffers from organic brain disease.
60
1st name | Daimei |
Middle name | |
Last name | Sasayama |
Shinshu University School of Medicine
Department of Psychiatry
390-8621
3-1-1 Asahi, Matsumoto
0263372638
sasayama@shinshu-u.ac.jp
1st name | Daimei |
Middle name | |
Last name | Sasayama |
Shinshu University School of Medicine
Department of Psychiatry
390-8621
3-1-1 Asahi, Matsumoto
0263372638
sasayama@shinshu-u.ac.jp
Shinshu University
Shinshu University
Self funding
Shinshu University School of Medicine Medical Ethics Committee
3-1-1 Asahi, Matsumoto
0263-37-2572
mdrinri@shinshu-u.ac.jp
NO
2017 | Year | 01 | Month | 01 | Day |
https://www.sciencedirect.com/science/article/pii/S0303846722002712?via%3Dihub
Published
https://www.sciencedirect.com/science/article/pii/S0303846722002712?via%3Dihub
69
The salivary levels of IL-1beta, IL-6, IL-9, IL-12p70, IL-13, Chemokine CCL11 (Eotaxin), MIP-1alpha, RANTES, and VEGF were significantly higher in patients than controls. IL-1beta, IL-12p70, CCL11, and VEGF remained significant after controlling for possible confounding factors.
2022 | Year | 12 | Month | 22 | Day |
19 patients with MDD and 50 healthy controls
The levels of 27 cytokines in saliva were measured by multiplex bead array assay.
None
Salivary cytokine levels
Completed
2016 | Year | 12 | Month | 06 | Day |
2016 | Year | 12 | Month | 06 | Day |
2017 | Year | 01 | Month | 01 | Day |
2021 | Year | 03 | Month | 31 | Day |
2016 | Year | 12 | Month | 17 | Day |
2022 | Year | 12 | Month | 22 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028386
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