Unique ID issued by UMIN | UMIN000024701 |
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Receipt number | R000028422 |
Scientific Title | Novel approach to heart failure through the gut microbiota and its metabolite |
Date of disclosure of the study information | 2017/01/01 |
Last modified on | 2016/11/03 19:32:38 |
Novel approach to heart failure through the gut microbiota and its metabolite
Prevention and treatment of heart failure through the gut
Novel approach to heart failure through the gut microbiota and its metabolite
Prevention and treatment of heart failure through the gut
Japan |
heart failure
Cardiology |
Others
NO
To clarify the characterization of gut microbial metabolites in the patients with heart failure.
To clarify prebiotics and probiotics which can prevent or treat heart failure.
Safety,Efficacy
To elucidate the characterization of gut microbial metabolites in the patients with heart failure.
Gut microbiota and its metabolites in feces after co-culture with prebioticas or probiotics in Kobe University Human Intestinal Model (KUHIM).
Observational
20 | years-old | <= |
100 | years-old | >= |
Male and Female
heart failure group
=patients diagnosed as heart failure
Control group
=patients who have heart failure risk factors such as hypertension, diabetes, and/or arrhythmia, but who do not have heart failure.
1) patients whose serum creatinine of greater than or equal to 3.0 mg/dL
2) patients with malignancy
3) patients with autoimmune disease or chronic inflammatory state
4) patients with inflammatory bowel diseases or intestinal surgery
90
1st name | |
Middle name | |
Last name | Yamashita Tomoya |
Kobe University Hospital
Division of Cardiovascular Medicine
7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 6500017, Japan
078-382-5111
tomoya@med.kobe-u.ac.jp
1st name | |
Middle name | |
Last name | Yamashita Tomoya |
Kobe University Hospital
Division of Cardiovascular Medicine
7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 6500017, Japan
078-382-5111
tomoya@med.kobe-u.ac.jp
Division of Cardiovascular Medicine, Department of Internal Medicine,
Kobe University Graduate School of Medicine
Division of Cardiovascular Medicine, Department of Internal Medicine,
Kobe University Graduate School of Medicine
Self funding
Kobe university graduated school of science, technology, and innovation
NO
2017 | Year | 01 | Month | 01 | Day |
Unpublished
Preinitiation
2016 | Year | 11 | Month | 01 | Day |
2017 | Year | 01 | Month | 01 | Day |
We co-culture feces of heart failure patients with various prebiotics/probiotics in Kobe University Human Intestinal Model. The purpose of this study is to clarify the characterization of gut microbial metabolite, and identify the prebiotics/probiotics which can lead gut microbiota and its metabolites considered to be heart failure protective.
2016 | Year | 11 | Month | 03 | Day |
2016 | Year | 11 | Month | 03 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028422
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