Unique ID issued by UMIN | UMIN000024726 |
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Receipt number | R000028450 |
Scientific Title | Examination about the curative effect of Mirtazapine for the QOL of the pulmonary tumor patient. |
Date of disclosure of the study information | 2017/04/01 |
Last modified on | 2020/05/11 12:26:25 |
Examination about the curative effect of Mirtazapine for the QOL of the pulmonary tumor patient.
Examination about the curative effect of Mirtazapine for the QOL of the pulmonary tumor patient.
Examination about the curative effect of Mirtazapine for the QOL of the pulmonary tumor patient.
Examination about the curative effect of Mirtazapine for the QOL of the pulmonary tumor patient.
Japan |
Lung cancer and suspected case
Pneumology |
Malignancy
NO
To confirm that a lung cancer doubt patient has the symptom of depression and
it would be recovered by the early treatment.
Efficacy
Confirmatory
Change of the total Hospital Anxiety and Depression Scale (HADS) score before and after 4 weeks treatment with mirtazapine.
Quick Inventory of Depressive Symptomatology (QIDS-J),Clinical Global Impression of Improvement (CGI).The change of the total HADS score during the observation period in the non-group given mirtazapine.
A comparison of HADS in a mirtazapine treatment group and the non-treatment group.
Interventional
Parallel
Non-randomized
Open -no one is blinded
No treatment
3
Treatment
Medicine |
We carry out HADS (Hospital Anxiety and Depression Scale) to a patient of the lung cancer doubt, and having depressive symptom or not is screened. We give mirtazapine 15mg(after 14 days, up to 30mg) to patients more than 11 points day after day.After 4 weeks, we carry out HADS agein.
Patients who do not agree taking mirtazapine also carry HADS test agein after 4 week.
We carry out HADS to the patient (lower than HADS10 mark) without the depressive symptom equally four weeks later.
20 | years-old | <= |
75 | years-old | >= |
Male and Female
The patient who received written enough explanation about a purpose, a method, the significance of this study with a document agreement.
The patient who could not carry out HADS or was refused. The patient who has a history of the past with hypersensitivity for mirtazapine. The patient with a history of the past with brain disorder (including dementia and Parkinson's disease) of the tissue except the metastasis to brain.
The patient with the past of Mental disease medicine treatment except the sleep inducing drug within three months.
The patient with severe hepatic dysfunction or renal dysfunction.
The patients with the past of suicide consideration or suicide project.
The patients who receive medical treatment with heart trouble (myocardial infarction, angina, conduction disorder).
The patient with glaucoma or the intraocular pressure sthenia. The patients who receive medical treatment with dysuria.
During a pregnant woman, the nursing and the patient who may be pregnant.
The patient who takes a monoamine oxidase inhibitor (MAOI) within two weeks.
The patient who judged that the examination medical attendant was inappropriate.
60
1st name | Koichi |
Middle name | |
Last name | Takayama |
Kyoto Prefectural University of Medicine
Pulmonary Medicine
602-8566
465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566
075-251-5513
takayama@koto.kpu-m.ac.jp
1st name | Yoshiko |
Middle name | |
Last name | Kaneko |
Kyoto Prefectural University of Medicine
Pulmonary Medicine
602-8566
465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566
075-251-5513
kaneko-y@koto.kpu-m.ac.jp
Kyoto Prefectural University of Medicine
Kyoto Prefectural University of Medicine
Local Government
Kyoto Prefectural University of Medicine
465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566
075-251-5513
kaneko-y@koto.kpu-m.ac.jp
NO
2017 | Year | 04 | Month | 01 | Day |
http://kokyu-kpum.com/study/
Unpublished
https://upload.umin.ac.jp/cgi-bin/icdr/ctr_up_reg_f5.cgi
43
The results showed that patients with depression reported a worse quality of life than those without depression. Compared with no medication, the administration of mirtazapine alleviated depressive symptoms. Furthermore, the patients depressive status was affected by their physical symptoms, including coughing, tightness of chest, and dyspnea.
2020 | Year | 05 | Month | 11 | Day |
Patients who have been admitted to the hospital for bronchoscopy for detailed examination of lung cancer
A questionnaire survey was conducted at the time of hospitalization and first outpatient examination.
none
HADS
FACT-L
Preinitiation
2017 | Year | 04 | Month | 01 | Day |
2017 | Year | 04 | Month | 01 | Day |
2018 | Year | 08 | Month | 01 | Day |
2019 | Year | 03 | Month | 01 | Day |
2016 | Year | 11 | Month | 06 | Day |
2020 | Year | 05 | Month | 11 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028450
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