Unique ID issued by UMIN | UMIN000024793 |
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Receipt number | R000028526 |
Scientific Title | Examination about the effect of the cytapheresis combination therapy for patients with inflammatory bowel disease during biologics induction and maintenance administration. |
Date of disclosure of the study information | 2016/11/10 |
Last modified on | 2018/11/20 21:57:26 |
Examination about the effect of the cytapheresis combination therapy for patients with inflammatory bowel disease during biologics induction and maintenance administration.
CAPBiologics
Examination about the effect of the cytapheresis combination therapy for patients with inflammatory bowel disease during biologics induction and maintenance administration.
CAPBiologics
Japan |
Crohn's disease
Ulcerative colitis
Gastroenterology |
Others
NO
The choice of the therapy has CAP therapy, and it has been already known that it is effective for treatment to use this together, but the synergistic detailed mechanism is not apparent.
The CAP therapy is able to remove granular leukocyte cell sorva an Ada column together, but cell sorva is able to remove lymphocytes.
B cells and the plasma cells are included in lymphocytes other than T cells and are aimed for the collection of of the data base about the effect that the removal of antibody forming cells gives in an antibiological preparation antibody level.
PK,PD
Confirmatory
Explanatory
Not applicable
When we show the change of the anti-drug antibody with the CAP therapy, CAP therapy and anti-TNF antibody preparation combination may produce a synergistic effect.
Observational
16 | years-old | <= |
70 | years-old | > |
Male and Female
(1) Crohn's disease made maintenance therapy with infliximab or adalimumab, the patients with ulcerative colitis.
(2) The patients who used CAP combination therapy.
none
40
1st name | |
Middle name | |
Last name | Hirotsugu Imaeda |
Shiga University of Medical Science
Division of Gastroenterology, Department of Medicine
Setatsukinowa, Otsu
077-548-2217
imaeda@belle.shiga-med.ac.jp
1st name | |
Middle name | |
Last name | Hirotsugu Imaeda |
Shiga University of Medical Science
Division of Gastroenterology, Department of Medicine
Setatsukinowa, Otsu
077-548-2217
http://www.ninai-sums.jp/study/gastrointestinal-medicine
imaeda@belle.shiga-med.ac.jp
Shiga University of Medical Science
Ministry of Health, Labour and Welfare
Japanese Governmental office
NO
2016 | Year | 11 | Month | 10 | Day |
Unpublished
Terminated
2015 | Year | 05 | Month | 12 | Day |
2015 | Year | 06 | Month | 01 | Day |
2020 | Year | 03 | Month | 31 | Day |
2020 | Year | 03 | Month | 31 | Day |
2020 | Year | 03 | Month | 31 | Day |
2021 | Year | 03 | Month | 31 | Day |
Effective
2016 | Year | 11 | Month | 10 | Day |
2018 | Year | 11 | Month | 20 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028526
Research Plan | |
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Registered date | File name |
2017/01/12 | 研究実施計画書等修正報告書 (1).pdf |
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