Unique ID issued by UMIN | UMIN000024935 |
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Receipt number | R000028688 |
Scientific Title | exosome-focused translational research for afatinib |
Date of disclosure of the study information | 2017/01/01 |
Last modified on | 2018/09/13 10:26:08 |
exosome-focused translational research for afatinib
EXTRA
exosome-focused translational research for afatinib
EXTRA
Japan |
Lung Cancer
Pneumology | Hematology and clinical oncology | Chest surgery |
Malignancy
YES
Effects of various exosome-encapsulating molecules (DNA, proteins, metabolites, etc.) in blood, on the therapeutic effect and tolerance acquisition of afatinib in EGFR gene mutation positive non-small cell lung cancer (NSCLC) patients were analyzed by various OMICs analysis / Trans- Consider by OMICs analysis.
Bio-availability
Exploratory
Others
Not applicable
Identification of pharmacological markers and resistance factors of afatinib using exosome-derived molecules
Relationship between various factors and response rate, disease control ratio, progression-free survival time, overall survival time
Consideration of compatibility of results between serum specimen and serum exosome specimen
Observational
20 | years-old | <= |
Not applicable |
Male and Female
non small cell lung cancer
diagnosed adenocarcinoma
having Ex19 mutation, Ex.21 mutation, uncommon mutation
using afatinib as first line treatment
ECOG PS 0,1
healthy patient
It is expected to survive for at least 3 months.
writing consent is obtained
Illegal disorders such as idiopathic pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, active radiation pneumonitis, drug pneumonia, etc. are complicated
synchronous or allochronic malignancies
having the history of preoperative anticancer treatments
60
1st name | |
Middle name | |
Last name | Nobuhiko Seki |
Teikyo University School of Medicine
internal medicine
2-11-1 Kaga, Itabashi-ku Tokyo
03-3964-1231
nseki@med.teikyo-u.ac.jp
1st name | |
Middle name | |
Last name | Noriyuki Matsutani |
Teikyo University School of Medicine
Surgery
2-11-1 Kaga, Itabashi-ku, Tokyo
03-3964-1231
http://teikyohaigeka.com/
matsutan@med.teikyo-u.ac.jp
Teikyo University School of Medicine
Nippon Boehringer Ingelheim Co., Ltd.
Profit organization
NO
帝京大学(東京都)
都立駒込病院(東京都)
虎ノ門病院(東京都)
慶應義塾大学(東京都)
東京医科大学(東京都)
東京医科大学八王子医療センター(東京都)
東京女子医科大学(東京都)
日本大学医学部附属板橋病院(東京都)
国立病院機構 弘前病院(青森県)
弘前大学(青森県)
浜松医科大学(静岡県)
山形県立中央病院(山形県)
埼玉県立循環器・呼吸器病センター(埼玉県)
星ヶ丘医療センター(大阪府)
国立病院機構 水戸医療センター(茨城県)
国立病院機構 茨城東病院(茨城県)
岡山赤十字病院(岡山県)
川崎医科大学附属川崎病院(岡山県)
伊勢赤十字病院(三重県)
昭和大学横浜市北部病院(神奈川県)
2017 | Year | 01 | Month | 01 | Day |
Unpublished
No longer recruiting
2016 | Year | 10 | Month | 14 | Day |
2017 | Year | 01 | Month | 01 | Day |
blood sampling
2016 | Year | 11 | Month | 21 | Day |
2018 | Year | 09 | Month | 13 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000028688
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