Unique ID issued by UMIN | UMIN000025813 |
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Receipt number | R000029568 |
Scientific Title | The effects of Lactobacillus reuteri probiotics on peri-implantitis: a randomized placebo-controlled study |
Date of disclosure of the study information | 2017/01/26 |
Last modified on | 2017/07/25 09:47:19 |
The effects of Lactobacillus reuteri probiotics on peri-implantitis: a randomized placebo-controlled study
Probiotics for peri-implantitis patients
The effects of Lactobacillus reuteri probiotics on peri-implantitis: a randomized placebo-controlled study
Probiotics for peri-implantitis patients
Japan |
peri-implantitis
Dental medicine |
Others
NO
To investigate the effects of a probiotic tablet containing L. reuteri in peri-implantitis patients.
Efficacy
Exploratory
Pragmatic
Phase II
periodontal bacterial count (4wks, 12wks, 24wks after the intake of probiotics )
probing pocket depth, bleeding on probing, modified gingival index, modified plaque index at 4wks, 12wks, 24wks after the intake of probiotics
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
NO
NO
Institution is not considered as adjustment factor.
NO
No need to know
2
Treatment
Food |
Subject took one tablet containing L. reuteri probiotics a day for 6 months (intervention group)
Subject took one tablet non-containing L. reuteri probiotics a day for 6 months (control group)
20 | years-old | <= |
Not applicable |
Male and Female
probing pocket depths are more than 4 mm and less than 7 mm
bleeding or suppuration on probing (+)
marginal bone loss > 2 mm
patients with uncontrolled systematic disease
patients who took antibiotics within 3 months
pregnant women
patients allergic to antibiotics
30
1st name | |
Middle name | |
Last name | Ryuji Hosokawa |
Kyushu Dental University
Department of Oral Reconstruction and Rehabilitation
2-6-1 Manazuru, Kokurakita, Kitakyushu, Fukuoka
093-285-3100
hosokawa@kyu-dent.ac.jp
1st name | |
Middle name | |
Last name | Chihiro Masaki |
Kyushu Dental University
Department of Oral Reconstruction and Rehabilitation
2-6-1 Manazuru, Kokurakita, Kitakyushu, Fukuoka
093-285-3100
masaki@kyu-dent.ac.jp
Department of Oral Reconstruction and Rehabilitation, Kyushu Dental University
internal fund
Other
NO
九州歯科大学病院(福岡県),たかはし歯科(愛媛県),つかもと歯科・小児歯科医院(佐賀県),吉田歯科医院(大阪府),原歯科医院(佐賀県),あべやま歯科クリニック(福岡県),中村歯科医院(佐賀県)
2017 | Year | 01 | Month | 26 | Day |
Published
Although the number of bacteria decreased after the administration of azithromycin in both groups, they increased again thereafter. No significant difference was observed in bacterial numbers between the two groups. Although PPD in the probiotics group was significantly lower at 4 and 24 weeks than at 0 weeks (p < 0.05), a significant decrease did not occur in the placebo group. The mBI score at 24 weeks was significantly lower in the probiotics group than in the placebo group (p <0.05). No significant difference was observed in BOP or mPI between the two groups.
Completed
2015 | Year | 07 | Month | 30 | Day |
2016 | Year | 03 | Month | 01 | Day |
2017 | Year | 01 | Month | 08 | Day |
2017 | Year | 03 | Month | 30 | Day |
2017 | Year | 03 | Month | 30 | Day |
2017 | Year | 03 | Month | 30 | Day |
2017 | Year | 01 | Month | 23 | Day |
2017 | Year | 07 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029568
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