Unique ID issued by UMIN | UMIN000026016 |
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Receipt number | R000029905 |
Scientific Title | Measuring HMGB1 and soluble forms of Toll-like Receptors in patients with migraine, tension-type headache, and stroke |
Date of disclosure of the study information | 2017/02/24 |
Last modified on | 2019/01/07 10:07:14 |
Measuring HMGB1 and soluble forms of Toll-like Receptors in patients with migraine, tension-type headache, and stroke
HMGB1 and soluble Toll-like Receptors in Migraine, tension-type headache, and stroke
Measuring HMGB1 and soluble forms of Toll-like Receptors in patients with migraine, tension-type headache, and stroke
HMGB1 and soluble Toll-like Receptors in Migraine, tension-type headache, and stroke
Japan |
migraine, tension-type headache, stroke
Neurology |
Others
NO
To clarify the dynamics of serum HMGB1 and soluble forms of Toll-like Receptors in patients affected by migraine, tension-type headache, and stroke.
To assess the utility of serum HMGB1 and soluble forms of Toll-like Receptors as disease biomarkers.
Others
Chronic headache disorders, such as migraine and tension-type headache, and stroke are among the most common neurological disorders. We previously demonstratated that cortical spreading depression, which is closely related to pathophysiological mechanism of migraine and stroke, causes HMGB1 recelase from cortical neurons and that released HMGB1 acts on Toll-like Receptors on miclogia. In the present study, we aim to assess the utility of serum HMGB1 and soluble forms of Toll-like Receptors as disease biomarkers.
Exploratory
Others
Not applicable
serum HMGB1 level
serum soluble forms of Toll-like Receptors
Correlations between the above concentrations and disease severity
Observational
15 | years-old | <= |
90 | years-old | >= |
Male and Female
1. Those from whom informed consent is obtained
2. Those who are at least 15 years of age
3. Those who satisfy the diagnostic criteria of migraine or tension-type headache
4. Those who are diagnosed with stroke by radiological examinations, such as MRI and CT
1. Those who do not agree to join the study
2. Those who are considered as ineligible by the attending physician
50
1st name | |
Middle name | |
Last name | Mamoru Shibata |
Keio University School of Medicine
Depatment of Neurology
35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
03-5363-3788
mshibata@a7.keio.jp
1st name | |
Middle name | |
Last name | Mamoru Shibata |
Keio University School of Medicine
Department of Neurology
35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
03-5363-3788
mshibata@a7.keio.jp
Department of Neurology, Keio University School of Medicine
Keio University School of Medicine
Other
NO
2017 | Year | 02 | Month | 24 | Day |
Unpublished
Terminated
2017 | Year | 02 | Month | 06 | Day |
2017 | Year | 04 | Month | 01 | Day |
2019 | Year | 01 | Month | 07 | Day |
2019 | Year | 01 | Month | 07 | Day |
2019 | Year | 01 | Month | 07 | Day |
2019 | Year | 01 | Month | 07 | Day |
Nothing
2017 | Year | 02 | Month | 06 | Day |
2019 | Year | 01 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029905
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