Unique ID issued by UMIN | UMIN000026262 |
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Receipt number | R000030056 |
Scientific Title | Location of cystic lesion and the Incidence of Pancreatic Cancer Concomitant with Intraductal Papillary Mucinous Neoplasm(IPMN) |
Date of disclosure of the study information | 2017/02/22 |
Last modified on | 2020/06/08 17:03:24 |
Location of cystic lesion and the Incidence of Pancreatic Cancer Concomitant with Intraductal Papillary Mucinous Neoplasm(IPMN)
Cyst location and pancreatic cancer with IPMN
Location of cystic lesion and the Incidence of Pancreatic Cancer Concomitant with Intraductal Papillary Mucinous Neoplasm(IPMN)
Cyst location and pancreatic cancer with IPMN
Japan |
intraductal papillary mucnous neoplasm
Hepato-biliary-pancreatic medicine | Hepato-biliary-pancreatic surgery |
Malignancy
NO
Cancer-specific survival of PDAC with IPMN was significantly poorer compared with invasive IPMN. However, there was no description of the risk factors of PDAC concomitant with IPMN in The recent guideline for IPMNs. Therefore, we investigated the association of the location of cysts with the incidence of PDAC concomitant with IPMN.
Others
The relationship between location of cystic lesion and the Incidence of Pancreatic Cancer Concomitant with IPMN
Confirmatory
Others
Not applicable
The relationship between location of cystic lesion and the Incidence of Pancreatic Cancer Concomitant with IPMN
The relationship between family history of pancreatic cancer, diabetes mellitus, alcohol consumption, BMI and smoking history, and the incidence of IPMN with an associated invasive carcinoma or pancreatic cancer concomitant with IPMN
Observational
20 | years-old | <= |
100 | years-old | >= |
Male and Female
more than 20 years old
None
164
1st name | Atsuhiro |
Middle name | |
Last name | Masuda |
Kobe University Hospital
Dep. of Gastroenterology
6500017
7-5-1 Kusunoki-cho Chuo-ku Kobe
078-382-6305
atmasuda@med.kobe-u.ac.jp
1st name | Atsuhiro |
Middle name | |
Last name | Masuda |
Kobe University Hospital
Dep. of Gastroenterology
6500017
7-5-1 Kusunoki-cho Chuo-ku Kobe
078-382-6305
atmasuda@med.kobe-u.ac.jp
Division of Gastroenterology, Department of Internal medicine, Kobe University Graduate School of Medicine
Division of Gastroenterology, Department of Internal medicine, Kobe University Graduate School of Medicine
Self funding
None
None
CTRC
7-5-1, Kusunoki-cho, Kobe
078-382-6669
rinri@med.kobe-u.ac.jp
NO
2017 | Year | 02 | Month | 22 | Day |
https://www.med.kobe-u.ac.jp/gi/pdf/study/ipmn-mrcp.pdf
Published
https://pubmed.ncbi.nlm.nih.gov/29685673/?from_term=ikagawa+takuya&from_exact_term=ikegawa+takuya&fr
141
Multiple cyst-existing regions (two or more regions) correlated with the incidence of PDAC concomitant with IPMN (PDAC concomitant with IPMN in one region vs. two or more regions: 3/66 vs. 13/75, multivariable odds ratio [OR] = 4.11, 95% confidence interval [CI] = 1.22 to 18.8, P = 0.02). In contrast, multiple cyst-existing regions did not correlate with the incidence of IPMN (invasive IPMN in one region vs. two or more regions: 13/66 vs. 18/75, OR = 1.19, 95% CI = 0.52 to 2.76, P = 0.67).
2020 | Year | 06 | Month | 08 | Day |
Subjects comprised 141 patients undergoing resection for IPMN (Non-invasive IPMN (IPMN with low-to high-grade dysplasia): N = 94, invasive IPMN: N = 31, and PDAC concomitant with IPMN: N = 16) between November 2000 and February 2017.
Subjects comprised 141 patients undergoing resection for IPMN (Non-invasive IPMN (IPMN with low-to high-grade dysplasia): N = 94, invasive IPMN: N = 31, and PDAC concomitant with IPMN: N = 16) between November 2000 and February 2017.
none
A logistic regression analysis was performed to assess the relationship between the number of cyst-existing regions (one region/two or more regions) and incidence of PDAC concomitant with IPMN, adjusted by clinical characteristics. Cyst-existing regions were defined by the number of anatomical parts of the pancreas: the head/body/tail of the pancreas.
Main results already published
2016 | Year | 11 | Month | 09 | Day |
2016 | Year | 11 | Month | 05 | Day |
2016 | Year | 11 | Month | 09 | Day |
2018 | Year | 12 | Month | 31 | Day |
2018 | Year | 12 | Month | 31 | Day |
2018 | Year | 12 | Month | 31 | Day |
2018 | Year | 12 | Month | 31 | Day |
retrospective study
164 consecutive patients of IPMN (N=142) or PDAC concomitant with IPMN (N=22) who underwent surgical resection at Kobe University Hospital between April 2008 and February 2017 were collected.
Survey items
age, body mass index (BMI), sex, diabetes mellitus (present or absent), family history of pancreatic cancer (present or absent), alcohol consumption (> 50 g/day or < 50 g/day), history of smoking, macroscopic type of IPMN (main duct type, mixed type, or branch duct type), mucin phenotype(gastric, intestinal, pancreatobiliary, or oncocytic), diameter of main pancreatic duct, nodule in cyst, diameter of cyst and location of cystic lesion.
2017 | Year | 02 | Month | 22 | Day |
2020 | Year | 06 | Month | 08 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000030056
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