Unique ID issued by UMIN | UMIN000027087 |
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Receipt number | R000030909 |
Scientific Title | Evaluation of endogenous analgesia in patients with chronic low back pain |
Date of disclosure of the study information | 2017/04/25 |
Last modified on | 2018/09/12 14:33:45 |
Evaluation of endogenous analgesia in patients with chronic low back pain
Evaluation of endogenous analgesia in patients with chronic low back pain
Evaluation of endogenous analgesia in patients with chronic low back pain
Evaluation of endogenous analgesia in patients with chronic low back pain
Japan |
chronic low back pain
Orthopedics |
Others
NO
Endogenous analgesic system plays an important role when the excessive pain is applied to the body. It involves descending pain inhibitory system and endogenous opioid. Dysfunction of the endogenous analgesic system causes chronic pain. Low back pain has a large number of affected patients, so establishment of appropriate low back pain treatment is required. It has been reported that the function of the endogenous analgesic system is decreased in various chronic pain patients including chronic arthralgia (Lewis et al., J Pain 2012; 10: 936-44.). In these cases, the medicine that activates the endogenous analgesic system is considered to be suitable as a treatment. However, there have been no reports that evaluate the function of the endogenous analgesic system of patients with chronic low back pain. In this study, we will evaluate the function of endogenous analgesic system of chronic low back pain patients. If the dysfunction of endogenous analgesic system is revealed, new evidence-based therapies can be established.
Others
we will evaluate the function of endogenous analgesic system of chronic low back pain patients.
Change of Numerical Rating Scale
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Prevention
Maneuver |
conditioned pain modulation
test stimulation1:pressure, 30 seconds
condition stimulation :cold water, 1 minutes
test stimulation2:pressure, 30 seconds
Not applicable |
Not applicable |
Male and Female
Patients:30 patients with chronic low back pain .
Control: 30 healthy volunteers.
Informed concent is essential.
1. Healthy volunteers cannot have any chronic pain.
2. Who cannnot understand the protocol of this study because of psyciatric disorder or dimentia.
3. Who cannot tolerate the stimulation.
60
1st name | |
Middle name | |
Last name | Hideaki Obata |
Fukushima Medical University
Center for Pain Management, Department of Anesthesiology
Hikarigaoka 1, Fukushima-City, Fukushima-Pref, JAPAN
024-547-1111
stoppain@fmu.ac.jp
1st name | |
Middle name | |
Last name | Yuko Nakano |
Fukushima Medical University
Department of Anesthesiology
Hikarigaoka 1, Fukushima-City, Fukushima-Pref, JAPAN
024-547-1111
masui@fmu.ac.jp
Fukushima Medical University
Self funding
Self funding
NO
福島県立医科大学附属病院(福島県)
2017 | Year | 04 | Month | 25 | Day |
Unpublished
Enrolling by invitation
2017 | Year | 01 | Month | 01 | Day |
2017 | Year | 04 | Month | 25 | Day |
2017 | Year | 04 | Month | 21 | Day |
2018 | Year | 09 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000030909
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