Unique ID issued by UMIN | UMIN000027582 |
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Receipt number | R000031586 |
Scientific Title | The relation between increased platelet reactivity during PCI and peri-procedural myocardial injury: comparison of clopidogrel with prasugrel |
Date of disclosure of the study information | 2017/10/01 |
Last modified on | 2019/12/03 09:16:03 |
The relation between increased platelet reactivity during PCI and peri-procedural myocardial injury: comparison of clopidogrel with prasugrel
The relation between increased platelet reactivity during PCI and peri-procedural myocardial injury
The relation between increased platelet reactivity during PCI and peri-procedural myocardial injury: comparison of clopidogrel with prasugrel
The relation between increased platelet reactivity during PCI and peri-procedural myocardial injury
Japan |
effort angina
Cardiology |
Others
NO
To compare the platelet reactivity during PCI and the occurrence of PMI between patients with clopidogrel and prasugrel.
Safety,Efficacy
the occurrence rate of PMI
(definition of PMI)
High-sensitive Troponin-T (hs-TnT) was measured before and 24 hours after PCI. In patients with normal (<99th percentile URL) baseline hs-TnT concentrations, PMI was defined as elevation of hs-TnT >5*99th percentile URL 24 hours after PCI. If the baseline hs-TnT values are elevated and are stable or falling, then a rise of > 20% is required for the diagnosis of PMI.
PRU value before and after PCI.
the serial change in platelet reactivity during elective PCI.
the correlation between the occurrence of PMI and PRU value before PCI and after PCI.
cardiovascular event and hemorrhagic event within 30 days after PCI.
Interventional
Parallel
Randomized
Individual
Open -no one is blinded
Active
2
Treatment
Medicine |
Patients in clopidogrel group underwent dual anti-platelet therapy with clopidogrel (75 mg daily) and aspirin (100 mg daily) between 7 days before PCI and 30 days after PCI.
Patients in prasugrel group underwent dual anti-platelet therapy with prasugrel (3.75 mg daily) and aspirin (100 mg daily) between 7 days before PCI and 30 days after PCI.
20 | years-old | <= |
90 | years-old | > |
Male and Female
Patients with effort angina scheduled for elective PCI.
hemorrhagic tendency
severe liver dysfunction(child-pugh grade C)
severe renal dysfunction (eGFR <30mL/min/1.73m2)
severe hypertension (systolic blood pressure >180)
have past history of cerebral infarction or transient ischemic attack
have intolerance with other thienopyridine derivative
160
1st name | Yusuke |
Middle name | |
Last name | Kawai |
Okayama City Hospital
Department of Cardiovascular Medicine
700-8557
3-20-1 Kitanagaseomote-cho Kita-ku Okayama, Japan
086-737-3000
jamkuhta@yahoo.co.jp
1st name | Yusuke |
Middle name | |
Last name | Kawai |
Okayama City Hospital
Department of Cardiovascular Medicine
700-8557
3-20-1 Kitanagaseomote-cho Kita-ku Okayama, Japan
086-737-3000
jamkuhta@yahoo.co.jp
Okayama City Hospital
Okayama University Hospital, Department of Cardiovascular Medicine
Other
Okayama City Hospital
700-8557 3-20-1 Kitanagaseomote-cho Kita-ku Okayama, Japan
0867373000
jamkuhta@yahoo.co.jp
NO
2017 | Year | 10 | Month | 01 | Day |
Unpublished
Completed
2017 | Year | 05 | Month | 29 | Day |
2017 | Year | 05 | Month | 26 | Day |
2017 | Year | 10 | Month | 01 | Day |
2019 | Year | 09 | Month | 30 | Day |
2017 | Year | 05 | Month | 31 | Day |
2019 | Year | 12 | Month | 03 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000031586
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