Unique ID issued by UMIN | UMIN000028842 |
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Receipt number | R000033010 |
Scientific Title | Analysis for mechanism of emerging the extremely high tolerance mutations against NS5A inhibitor in genotype 1b HCV after failing to DAAs |
Date of disclosure of the study information | 2017/09/01 |
Last modified on | 2021/07/27 00:28:44 |
Analysis for mechanism of emerging the extremely high tolerance mutations against NS5A inhibitor in genotype 1b HCV after failing to DAAs
Analysis for mechanism of emerging the extremely high tolerance mutations against NS5A inhibitor in genotype 1b HCV after failing to DAAs
Analysis for mechanism of emerging the extremely high tolerance mutations against NS5A inhibitor in genotype 1b HCV after failing to DAAs
Analysis for mechanism of emerging the extremely high tolerance mutations against NS5A inhibitor in genotype 1b HCV after failing to DAAs
Japan |
Chronic hepatitis C
Hepato-biliary-pancreatic medicine |
Others
NO
To investigate the mechanism emerging HCV strain carrying the extremely high tolerance mutation to NS5A inhibitors.
Others
To investigate the therapeutic strategy for patients with HCV carrying the extremely high tolerance against NS5A inhibitor; P29del or P32del, after failing to direct-acting antiviral agets (DAAs)therapy.
genetic analysis for HCV after failing to DAA therapy
Others,meta-analysis etc
Not applicable |
Not applicable |
Male and Female
1.Patients with genotype 1b HCV of genotype 1b with NS5A-P29del or P32del after failing to DAAs therapy.
2.Patients who have consent acquired for secondary use of preserved serum.
Patients who offers to decline participation in this study
10
1st name | Satoshi |
Middle name | |
Last name | Mochida |
Saitama Medical University
Department of Gastroenterology & Hepatology
350-0495
38 Morohongo, Moroyama-cho, Iruma-gun, Saitama, Japan
049-276-1198
smochida@saitama-med.ac.jp
1st name | Yoshihito |
Middle name | |
Last name | Uchida |
Saitama Medical University
Department of Gastroenterology & Hepatology
350-0495
38 Morohongo, Moroyama-cho, Iruma-gun, Saitama, Japan
049-276-1198
y_uchida@saitama-med.ac.jp
Saitama Medical University Department of Gastroenterology & Hepatology
Japan Agency for Medical Reserch and Development
Japanese Governmental office
the Institutional Review Board of Saitama Medical University Hospital
38 Morohongo, Moroyama-cho, Iruma-gun, Saitama, Japan
049-276-1125
hirb@saitama-med.ac.jp
NO
2017 | Year | 09 | Month | 01 | Day |
unpublished
Unpublished
unpublished
11
unpublished
2021 | Year | 07 | Month | 27 | Day |
unpublished
unpublished
none
unpublished
Main results already published
2017 | Year | 09 | Month | 01 | Day |
2017 | Year | 09 | Month | 01 | Day |
2017 | Year | 09 | Month | 01 | Day |
2018 | Year | 10 | Month | 31 | Day |
HCV genome are extracted from the conserved sera before and after DAA therapy, if avaible, at 1st, 2nd, 3rd and 4th week in treatment.
The obtained HCV genome are analyzed using direct-sequencing and ultra deep-sequencing.
2017 | Year | 08 | Month | 26 | Day |
2021 | Year | 07 | Month | 27 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033010
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