Unique ID issued by UMIN | UMIN000032945 |
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Receipt number | R000033184 |
Scientific Title | Evaluation of the magnetic susceptibility in the brain in patients with dementia |
Date of disclosure of the study information | 2018/06/11 |
Last modified on | 2022/06/15 10:22:56 |
Evaluation of the magnetic susceptibility in the brain in patients with dementia
Evaluation of the magnetic susceptibility in dementia
Evaluation of the magnetic susceptibility in the brain in patients with dementia
Evaluation of the magnetic susceptibility in dementia
Japan |
Dementia
Neurology | Psychiatry | Radiology |
Adult |
Others
NO
Comparison of the local magnetic susceptibility in quantitative susceptibility mapping (QSM) between Alzheimer's patients and cognitively normal control
Efficacy
Exploratory
Pragmatic
Not applicable
Comparison of the local magnetic susceptibility in quantitative susceptibility mapping (QSM) between Alzheimer's patients and cognitively normal control
1) Comparison of the local magnetic susceptibility in QSM among Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, mild cognitive impairment, and others
2) Comparison of the local cerebral blood flow in arterial spin labelling (ASL) between Alzheimer's patients and control group.
3) Comparison of the local diffusion parameters in diffusion tensor image (DTI) between Alzheimer's patients and control group.
4) Comparison of the local T1 and T2* values in quantitative parametrical mapping between Alzheimer's patients and control group.
5) Correlation between the local magnetic susceptibility and other imaging parameters.
6) Correlation between local magnetic susceptibility, cognitive function test, and blood exams
7) Correlation between local magnetic susceptibility and amyloid deposition in amyloid PET
Observational
20 | years-old | <= |
90 | years-old | > |
Male and Female
[Patients Group]
1) >20 and <90 years old
2) MRI examination within one month after obtaining informed consent, or susceptibility weighted images were scanned in past MRI exam.
3) informed consent is obtained after detailed explanation
[Control Group]
1) sex and age matched subjects with patients group
2) informed consent is obtained
[Patients Group]
(1)metallic implant and other MRI contraindicated objects
(2)pregnant female (including possible case)
(3)claustrophobia
[Control Group]
(1)the score of cognitive function test: MMSE<26, and MOCA-J<25
(2)abnormal MR findings or poor image quality due to motion artifact or other causes
90
1st name | Kohsuke |
Middle name | |
Last name | Kudo |
Hokkaido University Hospital
department of diagnostic and interventional radiology
060-8648
Kita 14 Nishi 5, Kita-ku, Sapporo, Hokkaido
011-706-7779
kkudo@huhp.hokudai.ac.jp
1st name | Kohsuke |
Middle name | |
Last name | Kudo |
Hokkaido University Hospital
department of diagnostic and interventional radiology
060-8648
Kita 14 Nishi 5, Kita-ku, Sapporo, Hokkaido
011-706-7779
kkudo@huhp.hokudai.ac.jp
Hokkaido University Hospital
Japan Agency for Medical Research and Development (AMED)
Japanese Governmental office
Japan
Hokkaido University Hospital
N14W5 Kita-ku Sapporo
011-716-1161
crjimu@huhp.hokudai.ac.jp
NO
北海道大学病院(北海道)、岩手医科大学(岩手県)、徳島大学(徳島県)、名古屋市立大学(愛知県)
2018 | Year | 06 | Month | 11 | Day |
Unpublished
No longer recruiting
2017 | Year | 09 | Month | 01 | Day |
2017 | Year | 09 | Month | 01 | Day |
2017 | Year | 09 | Month | 06 | Day |
2019 | Year | 04 | Month | 01 | Day |
2023 | Year | 03 | Month | 31 | Day |
2023 | Year | 03 | Month | 31 | Day |
2023 | Year | 03 | Month | 31 | Day |
observation study. Performing tests of cognitive function and MRI exams for dementia patients and cognitive normal control group.
2018 | Year | 06 | Month | 11 | Day |
2022 | Year | 06 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033184
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