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Name:
UMIN ID:

Recruitment status Open public recruiting
Unique ID issued by UMIN UMIN000029276
Receipt No. R000033444
Scientific Title Activity of brown adipose tissue and characteristics of physical function in humans
Date of disclosure of the study information 2017/12/01
Last modified on 2018/03/29

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Basic information
Public title Activity of brown adipose tissue and characteristics of physical function in humans
Acronym Activity of brown adipose tissue and characteristics of physical function in humans
Scientific Title Activity of brown adipose tissue and characteristics of physical function in humans
Scientific Title:Acronym Activity of brown adipose tissue and characteristics of physical function in humans
Region
Japan

Condition
Condition obesity or type 2 diabetes
Classification by specialty
Endocrinology and Metabolism Adult
Classification by malignancy Others
Genomic information NO

Objectives
Narrative objectives1 We hypothesized that the hepatokine selenoprotein P regulates the heat production in brown adipocytes. In fact, we found that hypothermia-resistance in selenoprotein P knockout mice and impairment in noradrenaline-induced heat production in primary brown adipocytes treated with selenoprotein P. In the current study, we measure blood levels of selenoprotein P in human subjects whose brown adipose tissue activity was measured by FDG-PET.
Basic objectives2 Others
Basic objectives -Others Many researchers pay attention to decreased brown adipose tissue activity in people with obesity or type 2 diabetes. However, its mechanism is not fully understood.
Trial characteristics_1
Trial characteristics_2
Developmental phase

Assessment
Primary outcomes The relationship between blood concentrations of hepatokine selenoprotein P and activity of brown adipose tissue measured by PET.
Key secondary outcomes

Base
Study type Observational

Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment

Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10

Eligibility
Age-lower limit
20 years-old <=
Age-upper limit
100 years-old >=
Gender Male and Female
Key inclusion criteria Healthy adult
Key exclusion criteria Cases who are judged as inadequate for the subjects in the current study by the corresponding doctors of the current study
Target sample size 30

Research contact person
Name of lead principal investigator
1st name
Middle name
Last name Hirofumi Misu
Organization Kanazawa University Graduate School of Medical Sciences
Division name Department of Endocrinology and Metabolism
Zip code
Address 13-1 Takara-machi, Kanazawa, Ishikawa,Japan
TEL +81-76-265-2712
Email hmisu@m-kanazawa.jp

Public contact
Name of contact person
1st name
Middle name
Last name Hirofumi Misu
Organization Kanazawa University Graduate School of Medical Sciences
Division name Department of Endocrinology and Metabolism
Zip code
Address 13-1 Takara-machi, Kanazawa, Ishikawa,Japan
TEL +81-76-265-2712
Homepage URL
Email hmisu@m-kanazawa.jp

Sponsor
Institute Kanazawa University Graduate School of Medical Sciences
Institute
Department

Funding Source
Organization Japan Science and Technology Agency
Organization
Division
Category of Funding Organization Japanese Governmental office
Nationality of Funding Organization

Other related organizations
Co-sponsor
Name of secondary funder(s)

IRB Contact (For public release)
Organization
Address
Tel
Email

Secondary IDs
Secondary IDs NO
Study ID_1
Org. issuing International ID_1
Study ID_2
Org. issuing International ID_2
IND to MHLW

Institutions
Institutions

Other administrative information
Date of disclosure of the study information
2017 Year 12 Month 01 Day

Related information
URL releasing protocol
Publication of results Unpublished

Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description

Progress
Recruitment status Open public recruiting
Date of protocol fixation
2017 Year 09 Month 25 Day
Date of IRB
Anticipated trial start date
2017 Year 12 Month 01 Day
Last follow-up date
Date of closure to data entry
Date trial data considered complete
Date analysis concluded

Other
Other related information We compare selenoprotein P concentrations with brown adipose activity in one group without intervention.

Management information
Registered date
2017 Year 09 Month 25 Day
Last modified on
2018 Year 03 Month 29 Day


Link to view the page
URL(English) https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033444

Research Plan
Registered date File name

Research case data specifications
Registered date File name

Research case data
Registered date File name


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