Unique ID issued by UMIN | UMIN000029394 |
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Receipt number | R000033484 |
Scientific Title | Hypotensive effects of Umezu polyphenols among community-dwelling hypertensive patients not requiring medication |
Date of disclosure of the study information | 2017/10/03 |
Last modified on | 2017/10/03 09:33:04 |
Hypotensive effects of Umezu polyphenols among community-dwelling hypertensive patients not requiring medication
Hypotensive effects of Umezu polyphenols
Hypotensive effects of Umezu polyphenols among community-dwelling hypertensive patients not requiring medication
Hypotensive effects of Umezu polyphenols
Japan |
Hypertension
Medicine in general | Cardiology |
Others
NO
Evaluate hypotensive effects of Umezu polyphenols.
Safety,Efficacy
Decrease of systolic blood pressure and diastolic blood pressure after 12 weeks of intake of Umezu polyphenols in
(1) blood pressure at home, and
(2) blood pressure at the examination site
Findings from blood tests (hematology and biochemistry)
Anthropometric factors
Self-perceived physical and mental health status evaluated with SF-8
Self-perceived Symptoms
Changes in data of annual health checkups
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
YES
NO
Institution is not considered as adjustment factor.
NO
No need to know
2
Prevention
Other |
Four capsules containing Umezu polyphenols (200 mg per capsule) daily for 12 weeks, followed by 2 weeks of wash-out period and 12 months of follow-up period with mail surveys every 3 months.
Four placebo capsules daily for 12 weeks, followed by 2 weeks of wash-out period and 12 months of follow-up period with mail surveys every 3 months.
Not applicable |
Not applicable |
Male and Female
People with high-normal blood pressure (systolic blood pressure (SBP), 130-139 mmHg; or diastolic blood pressure (DBP), 85-89 mmHg) or low- and moderate-risk grade I hypertension (SBP, 140-159 mmHg; or DBP, 90-99 mmHg) at the clinic, taking no antihypertensive agents.
(Recruited from people living in or working for a corporation in Minabe Town, Wakayama Prefecture, Japan, pursuant to Guidelines for the Management of Hypertension JSH 2009, published by the Japanese Society of Hypertension.)
(1) People who eat two or more Umeboshi (pickled plums) per day regularly, (2) people with ingestion difficulty, (3) people with history of serious chronic conditions including cerebrovascular disease, ischemic heart disease and cancer (malignant tumor), (4) people under medication for hypertension, (5) people who are pregnant or within 1 year after delivery, (6) people having night-shift work with night duty, (7) people who cannot participate in follow-up blood pressure measurements, and (8) people whose participation is judged to be inappropriate due to any other reason by the responsible physician.
100
1st name | |
Middle name | |
Last name | Shigeki Takemura |
Wakayama Medical University
Department of Hygiene, School of Medicine
811-1, Kimiidera, Wakayama, 641-8509, Japan
+81-(0)73-441-0646
steakmmi@wakayama-med.ac.jp
1st name | |
Middle name | |
Last name | Shigeki Takemura |
Wakayama Medical University
Department of Hygiene, School of Medicine
811-1, Kimiidera, Wakayama, 641-8509, Japan
+81-(0)73-441-0646
steakmmi@wakayama-med.ac.jp
Wakayama Medical University
Japan Society for the Promotion of Science
Japanese Governmental office
Kindai University
Wakayama Industry Promotion Foundation
NO
和歌山県立医科大学(和歌山県) (Wakayama Medical University (Wakayama Prefecture))
2017 | Year | 10 | Month | 03 | Day |
Partially published
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24790590/
Some potential effects of Umezu polyphenols to prevent blood pressure elevation and to improve self-perceived physical health were observed. After withdrawal of Umezu polyphenols, this self-perceived physical health gradually returned to the initial level within one year.
Main results already published
2013 | Year | 06 | Month | 21 | Day |
2013 | Year | 07 | Month | 11 | Day |
2015 | Year | 03 | Month | 31 | Day |
2017 | Year | 10 | Month | 03 | Day |
2017 | Year | 10 | Month | 03 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033484
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