Unique ID issued by UMIN | UMIN000029308 |
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Receipt number | R000033501 |
Scientific Title | Study on efficacy and safety as well as on the changes in blood purine compounds by the treatment of patients with amyotrophic lateral sclerosis with febuxostat and inosine in combination. |
Date of disclosure of the study information | 2018/09/30 |
Last modified on | 2017/09/27 12:50:35 |
Study on efficacy and safety as well as on the changes in blood purine compounds by the treatment of patients with amyotrophic lateral sclerosis with febuxostat and inosine in combination.
Effect of febuxostat and inosine on amyotrophic lateral sclerosis
Study on efficacy and safety as well as on the changes in blood purine compounds by the treatment of patients with amyotrophic lateral sclerosis with febuxostat and inosine in combination.
Effect of febuxostat and inosine on amyotrophic lateral sclerosis
Japan |
Amyotrophic lateral sclerosis
Neurology |
Others
NO
Examine efficacy and safety of simultaneous administration of febuxostat and inosine for patients with amyotrophic lateral sclerosis.
Safety,Efficacy
Exploratory
Others
Not applicable
Difference of ALSFRS-R between before and after the treatment
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
Febuxostat 20 mg, Inosine 500 mg, twice a day for 14 days
20 | years-old | <= |
80 | years-old | >= |
Male and Female
1. Japanese patients with 20 to 80 years of age who are the outpatients of Teikyo University Hospital
2. Patients who have been diagnosed as amyotrophic lateral sclerosis
1. Subject who has or had hypersensitivity, idiosyncracy (allergy) to drug.
2. Subjects taking azathioprine or mercaptopurine
3. Subject who has or had renal function disorder.
4. Subject with a history of gout, hyperuricemia or urolithiasis.
5. Patients who changed therapeutic drugs and treatment methods within 1 month before administration of test drugs
6. Subject who was judged not to be appropriate by the principal investigator or sub investigators by other reasons.
3
1st name | |
Middle name | |
Last name | Fumiaki Saito |
Teikyo University
Department of neurology, Faculty of Medicine
11-1, Kaga 2-chome, Itabashi-ku, Tokyo 173-8606, Japan
03-3964-1211
f-saito@med.teikyo-u.ac.jp
1st name | |
Middle name | |
Last name | Fumiaki Saito |
Teikyo University
Department of neurology, Faculty of Medicine
11-1, Kaga 2-chome, Itabashi-ku, Tokyo 173-8606, Japan
03-3964-1211
f-saito@med.teikyo-u.ac.jp
Teikyo University
StaGen CO. LTD
Profit organization
NO
2018 | Year | 09 | Month | 30 | Day |
Unpublished
Completed
2016 | Year | 05 | Month | 16 | Day |
2017 | Year | 07 | Month | 18 | Day |
2017 | Year | 09 | Month | 27 | Day |
2017 | Year | 09 | Month | 27 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033501
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