Unique ID issued by UMIN | UMIN000029367 |
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Receipt number | R000033563 |
Scientific Title | Comparison of MRD detection by multiparameter flow cytometry among EuroFlow, Kameda-flow and SRL-flow methods |
Date of disclosure of the study information | 2017/10/10 |
Last modified on | 2022/10/05 14:05:53 |
Comparison of MRD detection by multiparameter flow cytometry among EuroFlow, Kameda-flow and SRL-flow methods
Comparison of MRD detection by multiparameter flow cytometry
Comparison of MRD detection by multiparameter flow cytometry among EuroFlow, Kameda-flow and SRL-flow methods
Comparison of MRD detection by multiparameter flow cytometry
Japan |
Multiple myeloma
Hematology and clinical oncology |
Malignancy
NO
Comparison of minimal residual disease (MRD) levels among EuroFlow, Kameda-flow and SRL-flow methods
Efficacy
Correlation of minimal residual disease (MRD) levels among EuroFlow, Kameda-flow and SRL-flow methods
1) 1-year and 3-year progression-free survival (PFS) after MRD assessment.
2) 1-year and 3-year overall survival (OS) after MRD assessment.
3) MRD negativity
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patients with symptomatic multiple myeloma by IMWG criteria who achieved at least partial response (PR).
patients who are incapacitated are excluded.
30
1st name | Hiroyuki |
Middle name | |
Last name | Takamatsu |
Kanazawa University
Hematology/Respiratory Medicine
920-8641
13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, JAPAN
076-265-2276
takamaz@staff.kanazawa-u.ac.jp
1st name | Hiroyuki |
Middle name | |
Last name | Takamatsu |
Kanazawa University
Hematology/Respiratory Medicine
920-8641
13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, JAPAN
076-265-2276
takamaz@staff.kanazawa-u.ac.jp
Hematology/Respiratory Medicine, Faculty of Medicine,
Institute of Medical, Pharmaceutical and Health Sciences,
Kanazawa University
SRL Inc.
Profit organization
Kanazawa University
13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, JAPAN
076-265-2110
rinri@adm.kanazawa-u.ac.jp
NO
金沢大学附属病院(石川県)
2017 | Year | 10 | Month | 10 | Day |
https://www.nature.com/articles/s41598-021-89761-9.pdf
Published
https://www.nature.com/articles/s41598-021-89761-9
69
We found Duraclone is a good option to evaluate MRD as the EuroFlow 8-color 2-tube method in multiple myeloma but it should be used with caution and some discrepancies between them may have resulted because of the difference in the number of cells analyzed and antibody panels. Therefore, a sufficient cell acquisition number (more than 5 x 10*6) is essential to achieve high sensitivity in MRD detection in MM.
2022 | Year | 10 | Month | 05 | Day |
2021 | Year | 05 | Month | 27 | Day |
Patients with multiple myeloma
After getting the written informed concent, patients took part in this study.
non
Comparison of MRD levels between DuraClone and EuroFlow 8-color 2-tube methods.
Main results already published
2017 | Year | 06 | Month | 28 | Day |
2017 | Year | 06 | Month | 21 | Day |
2017 | Year | 11 | Month | 01 | Day |
2021 | Year | 03 | Month | 31 | Day |
Minimal residual disease (MRD) levels by EuroFlow, Kameda-flow and SRL-flow.
1 and 3 year-PFS post-MRD assessment.
1 and 3 year-OS post-MRD assessment.
2017 | Year | 10 | Month | 01 | Day |
2022 | Year | 10 | Month | 05 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033563
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