Unique ID issued by UMIN | UMIN000029889 |
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Receipt number | R000034142 |
Scientific Title | Pharmacokinetics of breath alcohol and acetaldehyde after drinking alcohol |
Date of disclosure of the study information | 2017/11/08 |
Last modified on | 2022/12/19 08:58:21 |
Pharmacokinetics of breath alcohol and acetaldehyde after drinking alcohol
Pharmacokinetics of breath alcohol and acetaldehyde after drinking alcohol
Pharmacokinetics of breath alcohol and acetaldehyde after drinking alcohol
Pharmacokinetics of breath alcohol and acetaldehyde after drinking alcohol
Japan |
A healthy adult
Not applicable | Adult |
Others
YES
To elucidate a relationship between pharmacokinetics of breath alcohol and acetaldehyde after drinking and alcohol sensitivity (ALDH2 and ADH1B genotypes)
PK,PD
Exploratory
Pragmatic
Not applicable
changes in breath alcohol and acetaldehyde concentrations after drinking alcohol
Alcohol sensitivity by alcohol patch test and ADH1B/ALDH2 genotypes based on PCR method using oral mucosa.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Prevention
Other |
Intervention is 3 days. On each day, a subject intakes 180ml alcohol beverage of different 3 concentrations (0.01g/kg of body weight (BW), 0.1g/kg of BW, 0.3g/kg of BW or 0.5g/kg of BW ethanol) within about 5 minutes. And then, he is sampled his exhaled gas over time (every 5-20 minutes) for 1 hour, 2.5 hours or 4 hours, respectively.
20 | years-old | <= |
Not applicable |
Male and Female
・20<= years-old
・Male and Female
・A person who has ever drunken a unit of alcohol.
・A person who is standard weight (=>18.5 and <25) based on BMI (body mass index)
・A person who is provided sufficient explanations about this study and consented to it in writing by his own free will
・a person who has ever had any allergy symptoms by drinking alcohol beverage
・a person who has any airway diseases or liver diseases
・a person who is probably pregnant or is during pregnancy
・a person who is during the lactation
・an inappropriate person for this study
60
1st name | Ayako |
Middle name | |
Last name | Himemiya-Hakucho |
Graduate School of Medicine, Yamaguchi University
Department of Legal Medicine
755-8505
Minami-kogushi 1-1-1, Ube, Yamaguchi 755-8505 JAPAN
0836-22-2234
fujimiya@yamaguchi-u.ac.jp
1st name | Ayako |
Middle name | |
Last name | Himemiya-Hakucho |
Graduate School of Medicine, Yamaguchi University
Department of Legal Medicine
755-8505
Minami-kogushi 1-1-1, Ube, Yamaguchi 755-8505 JAPAN
0836-22-2234
haku.a@yamaguchi-u.ac.jp
Yamaguchi University
Japan Society for the Promotion of Science
Japanese Governmental office
Center For Clinical Research, Yamaguchi University Hospital
Minami-kogushi 1-1-1, Ube, Yamaguchi 755-8505 JAPAN
0836-22-2428
me223@yamaguchi-u.ac.jp
NO
山口大学医学部(山口県)
2017 | Year | 11 | Month | 08 | Day |
Partially published
56
No longer recruiting
2017 | Year | 09 | Month | 19 | Day |
2017 | Year | 09 | Month | 19 | Day |
2018 | Year | 01 | Month | 15 | Day |
2023 | Year | 03 | Month | 31 | Day |
2024 | Year | 03 | Month | 31 | Day |
2017 | Year | 11 | Month | 08 | Day |
2022 | Year | 12 | Month | 19 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034142
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