Unique ID issued by UMIN | UMIN000030037 |
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Receipt number | R000034213 |
Scientific Title | Histidine-Rich Glycoprotein as a novel severity biomarker for sepsis: application to early treatment |
Date of disclosure of the study information | 2018/02/01 |
Last modified on | 2023/05/26 17:02:44 |
Histidine-Rich Glycoprotein as a novel severity biomarker for sepsis: application to early treatment
HRG as a novel severity biomarker for sepsis
Histidine-Rich Glycoprotein as a novel severity biomarker for sepsis: application to early treatment
HRG as a novel severity biomarker for sepsis
Japan |
Sepsis
Infectious disease | Laboratory medicine | Emergency medicine |
Intensive care medicine |
Others
NO
We focus on the HRG levels in patients with sepsis, and assess the significance of the difference between HRG levels in non-survivors and survivors.
Others
Biological significance
We confirm the time change of HRG levels in patients with sepsis, and examine the association with a clinical course and a prognosis.
We examine the change of HRG levels by the cause of sepsis.
Observational
20 | years-old | <= |
Not applicable |
Male and Female
Patients newly diagnosed sepsis: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, and organ dysfunction can be identified as an acute change in total SOFA score 2 points or more consequent to the infection.
Pregnancy and Under 20 years old
200
1st name | Hiroshi |
Middle name | |
Last name | Morimatsu |
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Department of Anesthesiology and Resuscitology
700-8558
2-5-1 Shikatacho, Kitaku, Okayama, Japan
086-235-7327
pb9b45wr@okayama-u.ac.jp
1st name | Naoya |
Middle name | |
Last name | Kawanoue |
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Department of Anesthesiology and Resuscitology
700-8558
2-5-1 Shikatacho, Kitaku, Okayama, Japan
086-235-7327
nao.kawa@s.okayama-u.ac.jp
Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Japan Agency for Medical Research and Development
Japanese Governmental office
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Ethics Committee
2-5-1 Shikatacho, Kitaku, Okayama, Japan
086-235-6938
mae6605@adm.okayama-u.ac.jp
NO
岡山大学病院(岡山県)
川崎医科大学附属病院(岡山県)
島根大学医学部附属病院(島根県)
鳥取大学医学部附属病院(鳥取県)
愛媛大学医学部附属病院(愛媛県)
香川大学医学部附属病院(香川県)
岡山医療センター(岡山県)
岡山済生会総合病院(岡山県)
岡山市立市民病院(岡山県)
岡山赤十字病院(岡山県)
川崎医科大学総合医療センター(岡山県)
津山中央病院(岡山県)
福山医療センター(広島県)
福山市民病院(広島県)
尾道市立市民病院(広島県)
香川県立中央病院(香川県)
香川労災病院(香川県)
姫路赤十字病院(兵庫県)
神戸赤十字病院(兵庫県)
2018 | Year | 02 | Month | 01 | Day |
http://www.okadaimasui.com/jp/
Published
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283426
201
Although there was no time x survivors/non-survivors interaction in the time courses of HRG (P=0.34), the main effect of generalized linear mixed models was significant (P<0.001).
In a univariate Cox proportional hazards model with each variable as a time-dependent covariate, higher HRG levels were significantly associated with a lower risk of mortality (hazard ratio, 0.85 [95%CI, 0.78-0.92]; P<0.001).
2023 | Year | 05 | Month | 26 | Day |
2023 | Year | 03 | Month | 29 | Day |
Patients with sepsis
Patients newly diagnosed with sepsis based on the Sepsis-3 definition were prospectively enrolled in the study. The inclusion criteria included admission to the ICU with an increase in the SOFA score by 2 points or more caused by a dysregulated host response to infection.
After obtaining written consent from patients or their relatives, blood samples were collected to be analyzed later for HRG, P-SEP, and PCT levels on days 1 (within 24 h of diagnosis of sepsis), 3, 5, and 7, while the patients stayed in the ICU.
None
The primary outcome of this study was all-cause mortality within 28 days of the initial sampling. The differences in the time courses of HRG levels between survivors and non-survivors were evaluated.
Completed
2018 | Year | 02 | Month | 01 | Day |
2018 | Year | 04 | Month | 24 | Day |
2018 | Year | 08 | Month | 16 | Day |
2019 | Year | 12 | Month | 19 | Day |
2020 | Year | 09 | Month | 30 | Day |
2020 | Year | 12 | Month | 31 | Day |
2021 | Year | 06 | Month | 30 | Day |
In the preliminary study, we found that the HRG levels in SIRS patients were significantly low.
2017 | Year | 11 | Month | 20 | Day |
2023 | Year | 05 | Month | 26 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034213
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