Unique ID issued by UMIN | UMIN000030364 |
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Receipt number | R000034668 |
Scientific Title | Study to evaluate NK cell and antioxidant potentiating effect by supplement Gnetin C resveratrol |
Date of disclosure of the study information | 2017/12/12 |
Last modified on | 2019/06/25 12:09:06 |
Study to evaluate NK cell and antioxidant potentiating effect by supplement Gnetin C resveratrol
Effect of Gnetin C resveratrol on NK cell and antioxidant function
Study to evaluate NK cell and antioxidant potentiating effect by supplement Gnetin C resveratrol
Effect of Gnetin C resveratrol on NK cell and antioxidant function
Japan |
Healthy adults
Adult |
Others
NO
To examine the effectiveness and safety of supplement Gnetin C resveratrol, we investigate kinetics of NK cell, antioxidant, lipid, and uric acid functions before and after oral administration of Gnetin C resveratrol or placebo as well as the safety profiles using healthy volunteers.
Safety,Efficacy
Confirmatory
Pragmatic
Phase I
Influence of oral administration of Gnetinc C resveratrol on the expression of NK related antigens and NK cell function during 4 weeks after its start
Gnetin C resveratrol related toxicity during 4 weeks after its oral administration
Influence of oral administration of Gnetin C resveratrol on the serum and urine antioxidant function and uric acid metabolism functionduring 4 weeks after its start
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
YES
NO
Institution is not considered as adjustment factor.
YES
No need to know
2
Treatment
Food |
Ingestion of 150 mg Gnetinc C resveratrol daily for 2 weeks
Ingestion of 150 mg placebo daily for 2 weeks
20 | years-old | <= |
60 | years-old | >= |
Male and Female
Drinking three times or less a week, normal liver and renal function that has been confirmed in a medical examination within one year, and consent by explanation and agreement documents.
Any of the following: currently receiving a drug therapy, currently having chronic diseases such as heart, lung, kidney, gastrointestinal, and inflammatory diseases, suffering from invasive cancer within five years, suffering from non-invasive cancer within a year, a history of smoking within one year, taking foods which contain resveratrol, supplements, vitamins within 2 weeks, pregnant or lactating, and a history of hypersensitivity to resveratrol or supplements including resveratrol.
12
1st name | Akiyoshi |
Middle name | |
Last name | Takami |
Aichi Medical University School of Medicine
Division of Hematology, Department of Internal Medicine
480-1195
1-1 Yazakokarimata, Nagakute, Japan 480-1195
0561-62-3311
takami-knz@umin.ac.jp
1st name | Akiyoshi |
Middle name | |
Last name | Takami |
Aichi Medical University School of Medicine
Division of Hematology, Department of Internal Medicine
480-1195
1-1 Yazakokarimata, Nagakute, Japan 480-1195
0561-62-3311
takami-knz@umin.ac.jp
Aichi Medical University
The Ministry of Education, Culture, Sports and Technology of Japan
Japanese Governmental office
Japan
Aichi Medical University Hospital Ethics Committee
1-1 Yazakokarimata, Nagakute, Japan 480-1195
0561-62-3311
amu_ethics@aichi-med-u.ac.jp
NO
愛知医科大学病院(愛知県)
2017 | Year | 12 | Month | 12 | Day |
https://www.mdpi.com/2072-6643/11/6/1403/htm
Published
https://www.mdpi.com/2072-6643/11/6/1403/htm
12
All subjects completed the study, with no side effects reported across the study duration. Gnetin-C supplementation demonstrated a statistically significant increase in the absolute number of circulating natural killer (NK) cells expressing the activating receptors NKG2D and NKp46. NK cells derived from subjects who received Gnetin-C for two weeks showed higher cytotoxicity against K562 target cells than those before receiving Gnetin-C.
2019 | Year | 06 | Month | 25 | Day |
2019 | Year | 06 | Month | 21 | Day |
Completed
2017 | Year | 12 | Month | 12 | Day |
2017 | Year | 12 | Month | 14 | Day |
2018 | Year | 01 | Month | 04 | Day |
2018 | Year | 06 | Month | 30 | Day |
2018 | Year | 07 | Month | 11 | Day |
2018 | Year | 07 | Month | 11 | Day |
2018 | Year | 12 | Month | 31 | Day |
2017 | Year | 12 | Month | 12 | Day |
2019 | Year | 06 | Month | 25 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034668
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