Unique ID issued by UMIN | UMIN000030432 |
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Receipt number | R000034745 |
Scientific Title | The effect of the blood concentrations of asymmetric dimethylarginine and arginine on the cerebrovascular CO2 reactivity during general anesthesia in the patients with chronic renal failure |
Date of disclosure of the study information | 2017/12/17 |
Last modified on | 2019/06/23 20:16:33 |
The effect of the blood concentrations of asymmetric dimethylarginine and arginine on the cerebrovascular CO2 reactivity during general anesthesia in the patients with chronic renal failure
Cerebrovascular CO2 reactivity during general anesthesia in patients with chronic renal failure
The effect of the blood concentrations of asymmetric dimethylarginine and arginine on the cerebrovascular CO2 reactivity during general anesthesia in the patients with chronic renal failure
Cerebrovascular CO2 reactivity during general anesthesia in patients with chronic renal failure
Japan |
In principal, chronic renal failure patients (creatinine concentration equal or more than 4mg) for planning living-related renal transplantation patients under general anesthesia
Anesthesiology |
Others
NO
To examine the cerebrovascular reactivity to CO2(CO2R) partial pressure in the chronic renal failure patients under general anesthesia.
Others
To examine the effect of blood concentration of BUN, creatinine, asymmetric dimethylargininase (ADMA), L-Arginine and L-Arginine/ADMA ratio on CO2R in the chronic renal failure patients.
Others
Others
Not applicable
The comparison of CO2R between the chronic renal failure patients and patients without it during general anesthesia.
Evaluation of the effect of blood concentration of BUN, creatinine, asymmetric dimethylargininase (ADMA), L-Arginine and L-Arginine/ADMA ratio on CO2R in the chronic renal failure patients.
Observational
15 | years-old | <= |
70 | years-old | >= |
Male and Female
1. Chronic renal failure cases caused by glomerulonephritis.
2. Cases whose blood creatinine concentrations are equal or more than 4mg/dL.
3. Cases who are undergoing renal plantation, arteriovenous shunt formation for hemodialysis and catheter implantation for continuous ambulatory peritoneal dialysis under general anesthesia.
4. Cases with controlled hypertension along with who criteria.
5. Control cases with American society of anesthesiologist physical status 1.
6. Control cases with estimated glomerular filtration rate equal or more than 60 ml/min/1.73m2.
7. Control cases who are undergoing nephrectomy or general surgery under general anesthesia.
1. Cases whose hemoglobin concentrations are below 8g/dL.
2. Cases who cannot measure the blood flow velocity in middle cerebral artery by transcranial Doppler.
3. Laparoscopic surgery cases.
4. Emergency cases.
5. Cases with pregnancy.
6. Cases with uncontrolled hypertension.
7. Cases with atrial fibrillation, paroxysmal atrial fibrillation and premature ventricular contraction more than 10 times per minute.
8. History of cerebrovascular disease.
9. History of angina pectoris.
10. Chronic renal failure caused by diabetes mellitus, hypertension, gout, liver disease, drug induced and pregnancy.
11. Control cases with estimated glomerular filtration rate below 60 ml/min/1.73m2.
64
1st name | Kazuyoshi |
Middle name | |
Last name | Ishida |
Yamaguchi University Graduate School of Medicine
Department of Anesthesiology
7558505
1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
0836-22-2291
ishid002@yamaguchi-u.ac.jp
1st name | Kazuyoshi |
Middle name | |
Last name | Ishida |
Yamaguchi University Graduate School of Medicine
Department of Anesthesiology
7558505
1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
0836-22-2291
ishid002@yamaguchi-u.ac.jp
Yamaguchi University Graduate School of Medicine
Ministry of education
Japanese Governmental office
Japan
Yamaguchi University hospital IRB center
1-1-1 Minamikogushi,Ube,Yamaguchi, Japan
0836-22-2428
me223@yamaguchi-u.ac.jp
NO
2017 | Year | 12 | Month | 17 | Day |
https://nsas.anesth.or.jp/App/Datura/sm/63/session/P2-27.html#P2-27-2
Partially published
https://link.springer.com/article/10.1007/s00540-017-2422-3
75
We examined cerebrovascular CO2 reactivity(CO2R) in chronic renal failure(CRF) patients(n 62) under general anesthesia,comparing those with the patients without CRF (controls n 13).Despite no significant differences in the absoluteand relative values of CO2R between the CRF and control groups,blood urea nitrogen(BUN) concentrations in the CRF group correlated inversely with both absolute and relative CO2R.L arginine concentrations in the CRF group correlated inversely with relative CO2R(n 16).
2019 | Year | 06 | Month | 23 | Day |
2017 | Year | 11 | Month | 04 | Day |
All patients in the CRF group had glomerulonephritis,blood creatinine concentration more than 4mg dl-1 with controlled blood pressure and hemoglobin concentration more than 8g dl-1,and were scheduled for living related renal transplantation.The 13 patients in the control group were classed as American Society of Anesthesiologists(ASA) physical status(PS)1.
Patients with DM, uncontrolled hypertension,
peripheral vascular disease, or neurological disease including cerebral vascular disease, as well as those with a Hb concentration < 8 g/dl were excluded from the study.
none
Evaluation of the absolute CO2R and reelative CO2R.Association between the CO2R and blood concentration of BUN,asymmetric dimethylarginine and L-arginine
Completed
2012 | Year | 03 | Month | 28 | Day |
2004 | Year | 08 | Month | 18 | Day |
2017 | Year | 12 | Month | 17 | Day |
2018 | Year | 03 | Month | 31 | Day |
2018 | Year | 09 | Month | 22 | Day |
2018 | Year | 09 | Month | 22 | Day |
2018 | Year | 12 | Month | 01 | Day |
This study is planning for evaluating the cerebrovascular reactivity to CO2 partial pressure by transcranial Doppler ultrasonography in chronic renal failure cases and compare it with control patients without renal failure.The association between the humoral factors such as BUN,creatinine asymmetric dimethylarginine and L arginine concentrations and CO2 cerebrovascular reactivity will be evaluated.Our institutional Medicine Ethics Committee for Human Study judged that the present study was observational prospective study.Thus,the start of the preset study was August 2004.UMIN ICDR registration for the present study was applied after starting the study.
2017 | Year | 12 | Month | 17 | Day |
2019 | Year | 06 | Month | 23 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034745
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