Unique ID issued by UMIN | UMIN000030965 |
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Receipt number | R000035132 |
Scientific Title | Crinical evaluation of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer |
Date of disclosure of the study information | 2018/01/29 |
Last modified on | 2021/02/02 13:42:35 |
Crinical evaluation of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer
Crinical evaluation of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer
Crinical evaluation of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer
Crinical evaluation of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer
Japan |
head and neck cancer
Oto-rhino-laryngology |
Malignancy
NO
The aim of this study was to evaluate the effect of zinc acetate for prevention of mucositis associated with radiotherapy in patients with head and neck cancer, and compare the grade of mucositis with histirical control.
Efficacy
Exploratory
The worst grade of pharyngeal mucositis
Pharyngeal mucositis during radiation therapy of every week
Interventional
Single arm
Non-randomized
Open -no one is blinded
Historical
NO
NO
Institution is not considered as adjustment factor.
NO
1
Prevention
Medicine |
oral medication of zinc acetate.medication starts from the beginning of radiation therapy.medication dose is 100mg/day,range 25-150mg associated with side effect of zinc acetate.medication period is 6-7weeks during radiation therapy.
20 | years-old | <= |
100 | years-old | >= |
Male and Female
1) WHO PS 0-2
2) Advanced head and neck cancer,oral cavity is irradiated
3) Treated by radiotherapy and concomitant chemotherapy with cisplatin
4) Onset of mucositis is certain
5) Not diagnosted as dementia
6) Satisfy the diagnostic criteria of zinc deficiency(clinical and subclinical) advocated by japanese society of clinical nutrition
1) Patients that subjective examination is difficult(i.e. patient with dementia, under 19 years old)
2) Patients under life-threatening situation.
3) Patients who is assesed by researcher as ungrammatical for this study
25
1st name | Takehito |
Middle name | |
Last name | Kishino |
Kagawa university hospital
Otolaryngology-Head and Neck Surgery
7610793
1750-1,Ikenobe,Miki-cho,Kita-gun,Kagawa
087-891-2214
kissie@med.kagawa-u.ac.jp
1st name | Takehito |
Middle name | |
Last name | Kishino |
Kagawa university hospital
Otolaryngology-Head and Neck Surgery
761-0793
1750-1,Ikenobe,Miki-cho,Kita-gun,Kagawa
087-891-2214
kissie@med.kagawa-u.ac.jp
Kagawa university hospital
Otolaryngology-Head and Neck Surgery
Self funding
Self funding
Kagawa university Institutional Review Board
1750-1,Ikenobe,Miki-cho,Kita-gun,Kagawa
0878985111
kissie@med.kagawa-u.ac.jp
NO
香川大学病院(香川県)
2018 | Year | 01 | Month | 29 | Day |
Unpublished
Completed
2018 | Year | 01 | Month | 22 | Day |
2018 | Year | 01 | Month | 12 | Day |
2018 | Year | 01 | Month | 29 | Day |
2020 | Year | 09 | Month | 30 | Day |
2018 | Year | 01 | Month | 24 | Day |
2021 | Year | 02 | Month | 02 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000035132
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