Unique ID issued by UMIN | UMIN000031055 |
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Receipt number | R000035462 |
Scientific Title | Impact of varenicline on gastric emptying and effect of domperidone in healthy adults |
Date of disclosure of the study information | 2018/01/30 |
Last modified on | 2019/01/31 13:43:48 |
Impact of varenicline on gastric emptying and effect of domperidone in healthy adults
varenicline and gastric emptying
Impact of varenicline on gastric emptying and effect of domperidone in healthy adults
varenicline and gastric emptying
Japan |
functional gastrointestinal disorder
Gastroenterology | Adult |
Others
NO
Varenicline, a nicotinic receptor agonist, is an agent that is frequently used to help smokers quit smoking. This medicine sometimes occurs gastrointestinal symptoms, although the mechanism remains uncertain. The purpose of the study is to clarify the impact of varenicline and domperidone, a novel antiemetic drug, on gastric emptying of healthy adults, using 13C gastric emptying breath test.
Safety
Comparison of gastric parameters (gastric emptying parameter, t-half) among different pretreatments (control, varenicline, domperidone, varenicline with domperidone)
Interventional
Cross-over
Randomized
Individual
Open -no one is blinded
No treatment
4
Treatment
Medicine |
no pretreatment (control)
pretreatment of varenicline 0.5mg
pretreatment of domperidone 10mg
pretreatment of varenicline 0.5mg with domperidone 10mg
20 | years-old | <= |
50 | years-old | >= |
Male
Adults not having gastrointestinal symptoms, and not taking prescription of gastrointestinal drugs or anti-psychological drugs.
Adults with current gastrointestinal disorders or past history of upper gastrointestinal operation.
10
1st name | |
Middle name | |
Last name | Takatsugu Yamamoto |
Teikyo University School of Medicine
Department of Internal Medicine
2-11-1, Kaga, Itabashi-ku, Tokyo
03-3964-1211
ymmt@med.teikyo-u.ac.jp
1st name | |
Middle name | |
Last name | Takatsugu Yamamoto |
Teikyo University School of Medicine
Department of Internal Medicine
2-11-1, Kaga, Itabashi-ku, Tokyo
03-3964-1211
ymmt@med.teikyo-u.ac.jp
Teikyo University
Teikyo University
Other
NO
2018 | Year | 01 | Month | 30 | Day |
Published
Completed
2017 | Year | 12 | Month | 01 | Day |
2017 | Year | 12 | Month | 15 | Day |
2018 | Year | 10 | Month | 31 | Day |
2018 | Year | 10 | Month | 31 | Day |
2018 | Year | 10 | Month | 31 | Day |
2019 | Year | 01 | Month | 31 | Day |
2018 | Year | 01 | Month | 30 | Day |
2019 | Year | 01 | Month | 31 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000035462
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