Unique ID issued by UMIN | UMIN000031563 |
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Receipt number | R000035848 |
Scientific Title | Effect of canagliflozin as an alternative drug from DPP-4 inhibitor on heart failure with diabetis melltus : the pilot study "Can canagliflozin HAve Not only hypoGlycemic but cardiac supportive Effect?" |
Date of disclosure of the study information | 2018/03/04 |
Last modified on | 2021/03/12 21:41:09 |
Effect of canagliflozin as an alternative drug from DPP-4 inhibitor on heart failure with diabetis melltus : the pilot study "Can canagliflozin HAve Not only hypoGlycemic but cardiac supportive Effect?"
CHANGE trial
Effect of canagliflozin as an alternative drug from DPP-4 inhibitor on heart failure with diabetis melltus : the pilot study "Can canagliflozin HAve Not only hypoGlycemic but cardiac supportive Effect?"
CHANGE trial
Japan |
chronic heart failure with type 2 diabetis mellitus
Cardiology |
Others
NO
To investigate the effect of canagliflozin as an alternative drug from DPP-4 inhibitor in heart failure with diabetis using BNP
Safety,Efficacy
the change of BNP at 6 months from baseline
1. Vital signs
2. Labolatory data: blood and urinary biomarkers
3. Cardiac function
4. Cardiac vascular event
Interventional
Parallel
Non-randomized
Open -no one is blinded
Active
2
Treatment
Medicine |
Change group: Start with canagliflozin 100mg/day and stop or reduce DPP-4 inhibitor for 6 months.
Non-Change group: Conventional therapy for diabetes and heart failure
20 | years-old | <= |
Not applicable |
Male and Female
1. Treated with DPP4 inhibitor
2. Heart failure patients with type 2 diabetes mellitus who have HbA1c 6.5% or more
1. End stage renal failure including eGFR<15ml/min/1.73m2 or dialytic therapy
2. Treated with SGLT2 inhibitor
3. Contraindications of SGLT2 inhibitor
4. Type 1 diabetes mellitus
5. The pregnant, breast feeder
6. BMI<18.5kg/m2
40
1st name | Kyosuke |
Middle name | |
Last name | Yanagawa |
Osaka Rosai Hospital
Division of Cardiology
5918025
1179-3 Nagasone-cho, Kita-ku, Sakai-City, Osaka
072-252-3561
k.yanagawa0217@osakah.johas.go.jp
1st name | Kyosuke |
Middle name | |
Last name | Yanagawa |
Osaka Rosai Hospital
Division of Cardiology
5918025
1179-3 Nagasone-cho, Kita-ku, Sakai-City, Osaka
072-252-3561
k.yanagawa0217@osakah.johas.go.jp
Osaka Rosai Hospital
None
Self funding
Osaka Rosai Hosipital
1179-3 Nagasone-cho, Kita-ku, Sakai-City, Osaka
0722523561
k.yanagawa0217@osakah.johas.go.jp
NO
2018 | Year | 03 | Month | 04 | Day |
Unpublished
Preinitiation
2018 | Year | 03 | Month | 01 | Day |
2018 | Year | 03 | Month | 01 | Day |
2020 | Year | 12 | Month | 31 | Day |
2018 | Year | 03 | Month | 03 | Day |
2021 | Year | 03 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000035848
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