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Name:
UMIN ID:

Recruitment status No longer recruiting
Unique ID issued by UMIN UMIN000032543
Receipt No. R000036108
Scientific Title The new physiological concept of carbon dioxide gas exchange in the human lungs.
Date of disclosure of the study information 2018/05/10
Last modified on 2018/11/09

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Basic information
Public title The new physiological concept of carbon dioxide gas exchange in the human lungs.
Acronym The new physiological concept of carbon dioxide gas exchange in the human lungs.
Scientific Title The new physiological concept of carbon dioxide gas exchange in the human lungs.
Scientific Title:Acronym The new physiological concept of carbon dioxide gas exchange in the human lungs.
Region
Japan

Condition
Condition Patients undergo elective surgery under general anesthesia
Classification by specialty
Pneumology Anesthesiology Operative medicine
Classification by malignancy Others
Genomic information NO

Objectives
Narrative objectives1 Vascular endothelial cells are constantly exposed to shear stress, the mechanical force generated by blood flow. Recently we demonstrated that shear stress stimulation induced stress strength-dependent H+ release followed by CO2 gas excretion from pulmonary arteriolar endothelial cells in rabbits. However, whether the mechanism exists in human is still unknown
Thus, we investigate the correlation between the end-experatory CO2 gas pressure and pulmonary artery blood flow in human.
Basic objectives2 Others
Basic objectives -Others physiologic
Trial characteristics_1
Trial characteristics_2
Developmental phase

Assessment
Primary outcomes Correlation between the end-expiratory CO2 gas pressure and pulmonary artery blood flow.
Key secondary outcomes

Base
Study type Observational

Study design
Basic design
Randomization
Randomization unit
Blinding
Control
Stratification
Dynamic allocation
Institution consideration
Blocking
Concealment

Intervention
No. of arms
Purpose of intervention
Type of intervention
Interventions/Control_1
Interventions/Control_2
Interventions/Control_3
Interventions/Control_4
Interventions/Control_5
Interventions/Control_6
Interventions/Control_7
Interventions/Control_8
Interventions/Control_9
Interventions/Control_10

Eligibility
Age-lower limit
20 years-old <=
Age-upper limit

Not applicable
Gender Male and Female
Key inclusion criteria Patients undergo elective surgery under general anesthesia and are scheduled to be monitored with TEE and Swan-ganz catheter.
Key exclusion criteria Patients decline participation in this study
Target sample size 30

Research contact person
Name of lead principal investigator
1st name
Middle name
Last name Takashi Ishida
Organization Shinshu University of Medicine
Division name Department of Anesthesiology and Resuscitology
Zip code
Address 3-1-1 Asahi, Matsumoto, Nagano, Japan
TEL 0263-37-2670
Email tisd@shinshu-u.ac.jp

Public contact
Name of contact person
1st name
Middle name
Last name Takashi Ishida
Organization Shinshu University of Medicine
Division name Department of Anesthesiology and Resuscitology
Zip code
Address 3-1-1 Asahi, Matsumoto, Nagano, Japan
TEL 0263-37-2670
Homepage URL
Email tisd@shinshu-u.ac.jp

Sponsor
Institute Shinshu University of Medicine
Institute
Department

Funding Source
Organization Shinshu University of Medicine Department of Anesthesiology and Resuscitology
Organization
Division
Category of Funding Organization Other
Nationality of Funding Organization

Other related organizations
Co-sponsor
Name of secondary funder(s)

IRB Contact (For public release)
Organization
Address
Tel
Email

Secondary IDs
Secondary IDs YES
Study ID_1 4035
Org. issuing International ID_1 Ethical committee of Shinshu University of Medicine
Study ID_2
Org. issuing International ID_2
IND to MHLW

Institutions
Institutions

Other administrative information
Date of disclosure of the study information
2018 Year 05 Month 10 Day

Related information
URL releasing protocol
Publication of results Unpublished

Result
URL related to results and publications
Number of participants that the trial has enrolled
Results
Results date posted
Results Delayed
Results Delay Reason
Date of the first journal publication of results
Baseline Characteristics
Participant flow
Adverse events
Outcome measures
Plan to share IPD
IPD sharing Plan description

Progress
Recruitment status No longer recruiting
Date of protocol fixation
2018 Year 05 Month 10 Day
Date of IRB
Anticipated trial start date
2018 Year 05 Month 10 Day
Last follow-up date
Date of closure to data entry
Date trial data considered complete
Date analysis concluded

Other
Other related information nothing

Management information
Registered date
2018 Year 05 Month 10 Day
Last modified on
2018 Year 11 Month 09 Day


Link to view the page
URL(English) https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000036108

Research Plan
Registered date File name

Research case data specifications
Registered date File name

Research case data
Registered date File name


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