Unique ID issued by UMIN | UMIN000031675 |
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Receipt number | R000036181 |
Scientific Title | Biomarker study of "A Phase III Trial of Docetaxel plus S-1 versus S-1 Alone in the Treatment of Curatively Resected Stage III Gastric Cancer (JACCRO GC-07(START-2))" |
Date of disclosure of the study information | 2018/03/12 |
Last modified on | 2021/01/18 23:18:24 |
Biomarker study of "A Phase III Trial of Docetaxel plus S-1 versus S-1 Alone in the Treatment of Curatively Resected Stage III Gastric Cancer (JACCRO GC-07(START-2))"
Biomarker study of "A Phase III Trial of Docetaxel plus S-1 versus S-1 Alone in the Treatment of Curatively Resected Stage III Gastric Cancer (JACCRO GC-07(START-2))"
Biomarker study of "A Phase III Trial of Docetaxel plus S-1 versus S-1 Alone in the Treatment of Curatively Resected Stage III Gastric Cancer (JACCRO GC-07(START-2))"
Biomarker study of "A Phase III Trial of Docetaxel plus S-1 versus S-1 Alone in the Treatment of Curatively Resected Stage III Gastric Cancer (JACCRO GC-07(START-2))"
Japan |
Gastric cancer
Gastroenterology | Gastrointestinal surgery |
Malignancy
NO
The purpose of this study is to identify predictive markers for docetaxel or S-1 in resectable gastric cancer.
Bio-availability
Exploratory
Pragmatic
Not applicable
To evaluate if TUBB3 expression serves as a predictor for docetaxel by analyzing PFS and OS in docetaxel plus S-1 arm and S-1 alone arm according to TUBB3 status.
To evaluate associations of PFS and OS with TS, DPYD, OPRT, and TYMP expression in S-1 alone arm.
To investigate correlation of PFS and OS with gene expression or mutations in each arm.
Observational
Not applicable |
Not applicable |
Male and Female
Patients who are registered in JACCRO GC-07 trial (UMIN 000010337), include the following:
(1) Resected tumor tissue samples available
(2) Approved to supply the tissue sample for this study by IRB.
(1) Patients who are considered as inadequate for study enrollment by investigators.
(2) Patients who refuse the use of samples for study.
800
1st name | Yu |
Middle name | |
Last name | Sunakawa |
St. Marianna University School of Medicine
Department of Clinical Oncology
216-8511
2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan
044-977-8111
y.sunakawa@marianna-u.ac.jp
1st name | Masashi |
Middle name | |
Last name | Fujii |
Japan Clinical Cancer Research Organization (JACCRO)
Office
101-0051
6F Jimbocho Kyowa Bldg. 1-64 Kanda-Jimbocho, Chiyoda-ku, Tokyo 101-0051
03-6811-0433
gc07.dc@jaccro.or.jp
Japan Clinical Cancer Research Organization (JACCRO)
Japan Clinical Cancer Research Organization (JACCRO
Other
Japan Clinical Cancer Research Organization Institutional Review Board
6F Jimbocho Kyowa Bldg. 1-64 Kanda-Jimbocho, Chiyoda-ku, Tokyo 101-0051
03-6811-0433
irb-jaccro@jaccro.or.jp
NO
聖マリアンナ医科大学(神奈川県)他
2018 | Year | 03 | Month | 12 | Day |
Unpublished
Enrolling by invitation
2018 | Year | 02 | Month | 07 | Day |
2018 | Year | 03 | Month | 01 | Day |
2022 | Year | 09 | Month | 30 | Day |
2022 | Year | 09 | Month | 30 | Day |
This is a translational study to identify novel biomarkers for adjuvant chemotherapy in resectable gastric cancer using tissue samples of the JACCRO GC-07 trial (START-2).
2018 | Year | 03 | Month | 12 | Day |
2021 | Year | 01 | Month | 18 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000036181
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