Unique ID issued by UMIN | UMIN000032121 |
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Receipt number | R000036332 |
Scientific Title | Study of evaluating therapeutic efficacy of intravitreal methotrexate in patients with primary intraocular lymphoma |
Date of disclosure of the study information | 2018/04/10 |
Last modified on | 2022/04/12 17:56:02 |
Study of evaluating therapeutic efficacy of intravitreal methotrexate in patients with primary intraocular lymphoma
Evaluation of therapeutic efficacy of intravitreal MTX in patients with PIOL
Study of evaluating therapeutic efficacy of intravitreal methotrexate in patients with primary intraocular lymphoma
Evaluation of therapeutic efficacy of intravitreal MTX in patients with PIOL
Japan |
primary intraocular lymphoma
Ophthalmology |
Malignancy
NO
We evaluate clinical safety of intravitreal methotrexate in patients with primary intraocular lymphoma.
Safety
Systemic and ophthalmological adverse effects and frequency
1. frequency of intraocular recurrences
2. recurrence-free survival
3. response rate
Interventional
Single arm
Non-randomized
Open -no one is blinded
Historical
1
Treatment
Medicine |
Patients receive 0.1ml of MTX (diluted to a concentration of 400ug/0.1ml using saline) by intravitreal injection.
MTX is administrated twice a week for 4 weeks, after that once a week for 4 weeks, and injected at every 4weeks x 12 times.
20 | years-old | <= |
80 | years-old | > |
Male and Female
patients with primary intraocular lymphoma
1. performance status 4
2. patients who participated in other clinical trials within three months
3. patients with severe allergy to MTX
4. patients who desire for childbearing
5. patients with severe dementia or psychiatric disorder
6. Patients suggested as ineligible by their attending physician
16
1st name | Kazuhisa |
Middle name | |
Last name | Sugiyama |
Kanazawa University Hospital
Department of opthalmology and visual science
9208641
13-1, Takara machi, Kanazawa, Ishikawa, JAPAN
076-265-2403
yuko-t@med.kanazawa-u.ac.jp
1st name | Yuko |
Middle name | |
Last name | Takemoto |
Kanazawa University Hospital
Department of opthalmology and visual science
9208641
13-1, Takara machi, Kanazawa, Ishikawa, JAPAN
076-265-2403
yuko-t@med.kanazawa-u.ac.jp
Kanazawa University Hospital
Kanazawa University Hospital
Self funding
Kanazawa University Hospital
13-1, Takara-machi, Kanazawa, Ishikawa
076-265-2049
crc.irb-knz@esct.jp
NO
2018 | Year | 04 | Month | 10 | Day |
stop the trial
Unpublished
stop the trial
0
stop the trial
2021 | Year | 04 | Month | 08 | Day |
stop the trial
stop the trial
stop the trial
stop the trial
Terminated
2018 | Year | 03 | Month | 28 | Day |
2018 | Year | 02 | Month | 28 | Day |
2018 | Year | 03 | Month | 28 | Day |
2019 | Year | 03 | Month | 27 | Day |
2019 | Year | 03 | Month | 27 | Day |
2019 | Year | 03 | Month | 27 | Day |
2019 | Year | 03 | Month | 27 | Day |
2018 | Year | 04 | Month | 05 | Day |
2022 | Year | 04 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000036332
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