Unique ID issued by UMIN | UMIN000031909 |
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Receipt number | R000036433 |
Scientific Title | Therapeutic Effect of Moxifloxacin versus Azithromycin on Refractory Chronic Endometritis |
Date of disclosure of the study information | 2018/03/26 |
Last modified on | 2022/09/15 17:07:12 |
Therapeutic Effect of Moxifloxacin versus Azithromycin on Refractory Chronic Endometritis
Therapeutic Effect of Moxifloxacin versus Azithromycin on Refractory Chronic Endometritis
Therapeutic Effect of Moxifloxacin versus Azithromycin on Refractory Chronic Endometritis
Therapeutic Effect of Moxifloxacin versus Azithromycin on Refractory Chronic Endometritis
Japan |
Chronic Endometritis
Obstetrics and Gynecology |
Others
NO
To compare the therapeutic effect of oral moxifloxacin versus azithromycin on refractory chronic endometritis
Efficacy
Histopathologic Cure Rate, Clinical Pregnancy Rate, Implantation Rate, Miscarriage Rate, Ongoing Pregnancy Rate
Live Birth Rate
Interventional
Parallel
Non-randomized
Open -no one is blinded
Active
2
Treatment
Medicine |
Oral Administration of Moxifloxacin 400mg/day for ten days
Oral Administration of Azithromycin 500mg/day for three days
20 | years-old | <= |
46 | years-old | > |
Female
Refractory Chronic Endometritis Resistant to Doxycycline and Metronidazole/Ciprofloxacin) Administration
Patients (i) with a history of hypersesitivity to azithromycin, moxifloxacin and/or other new quinolone agents, (ii) with a present illness of severe liver dysfunction, long QT, and/or hypokalemia, (iii) using antiarrhythmic agents, and (iv) having a pregnancy.
100
1st name | Kotaro |
Middle name | |
Last name | Kitaya |
Reproduction Clinic Osaka
IVF Center
5300011
Grand Front Osaka, Tower-A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, Japan
0661363344
kitaya@koto.kpu-m.ac.jp
1st name | Kotaro |
Middle name | |
Last name | Kitaya |
Reproduction Clinic Osaka
IVF Center
5300011
Grand Front Osaka, Tower-A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, Japan
0661363344
kitaya@koto.kpu-m.ac.jp
Reproduction Clinic Osaka
None
Other
Reproduction Clinic Osaka
Grand Front Osaka, Tower-A 15F, 4-20 Oofuka-cho, Kita-ku, Osaka, 530-0011, Japan
0661363344
sueshita@reposaka.jp
NO
2018 | Year | 03 | Month | 26 | Day |
Published
https://pubmed.ncbi.nlm.nih.gov/35653041/
48
The histopathologic cure rate of multi-drug resistant-chronic endometritis (MDR-CE) was similar between the moxifloxacin and azithromycin groups (79.2% vs 75.0%, OR 1.27, 95% CI 0.32-4.89, p value 0.73), as well as reproductive outcomes in subsequent embryo transfer cycles.
As a third-line treatment for MDR-CE, azithromycin may have a clinical advantage due to its shorter time administration periods.
2022 | Year | 09 | Month | 15 | Day |
2022 | Year | 06 | Month | 02 | Day |
Main results already published
2018 | Year | 03 | Month | 05 | Day |
2018 | Year | 03 | Month | 26 | Day |
2018 | Year | 03 | Month | 26 | Day |
2022 | Year | 03 | Month | 31 | Day |
2018 | Year | 03 | Month | 26 | Day |
2022 | Year | 09 | Month | 15 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000036433
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