Unique ID issued by UMIN | UMIN000032510 |
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Receipt number | R000037078 |
Scientific Title | Double blinded and placebo controlled examination to observe the effects of the water containing 7ppm molecular hydrogen on the EndPAT test |
Date of disclosure of the study information | 2018/05/10 |
Last modified on | 2018/05/09 16:39:13 |
Double blinded and placebo controlled examination to observe the effects of the water containing 7ppm molecular hydrogen on the EndPAT test
An examination to observe the effects of the water containing 7ppm molecular hydrogen on the EndPAT test
Double blinded and placebo controlled examination to observe the effects of the water containing 7ppm molecular hydrogen on the EndPAT test
An examination to observe the effects of the water containing 7ppm molecular hydrogen on the EndPAT test
Japan |
healthy subjects
Adult |
Others
NO
To improve the peripheral endothelial function
Efficacy
Improvement of Reactive hyperemia index(RHI)
Interventional
Parallel
Randomized
Individual
Double blind -all involved are blinded
Placebo
2
Prevention
Food |
Daily consumption of the water containing 7ppm molecular hydrogen for 14 days/Daily consumption of the placebo water for 14 days.
In detail, the healthy volunteers were informed individually about the significance of the study and the instruments of intended measurement. These volunteers enrolled in this study after providing their written informed consent. The subjects were randomly divided into two groups: a high H2 group and a placebo group. All the subjects were asked to fast, and avoid drinking caffeinated drinks or ingesting sugar for 6 hours before the test. Using the EndPad2000 System (Itamar Medical Inc.), we measured the baseline RHI using endothelium-dependent digital pulse amplitude testing (EndoPAT). Next, the subjects drank 500 ml of the placebo water or the high H2 water (continuing 7ppm H2) within 10 min, and after resting for 1 h the RHI was measured again. On the second day, 24 h after the first ingestion of placebo or high H2 water and before the second ingestion, the RHI was measured. After the measurements were obtained, they took a second drink, and the day after, they drank the placebo or the high H2 water once each day until the day before the last measurements at 14 days. In total, they drank the high H2 water or placebo 14 times.
The placebo water was prepared by filling up a PET bottle containing water with molecular nitrogen (N2) gas under 0.8 MPa to make the placebo bottles as firm as the bottles with the high H2 water containing 7ppm H2.
20 | years-old | <= |
Not applicable |
Male and Female
Healthy volunteers
All of the subjects took medications or dietary supplements or received medical treatments within 6 months before this study was performed.
68
1st name | |
Middle name | |
Last name | Toru Ishibashi |
Huis Ten Bosch Satellite H2 Clinic Hakata
Anicom Speciality Medical Institute
Department of rheumatology
2-1 Gion, Hakata-ku, Fukuoka 812-0038, Japan
+81-92-282-5005
tishibashi@h2-lab.jp
1st name | |
Middle name | |
Last name | Toru Ishibashi |
Huis Ten Bosch Satellite H2 Clinic Hakata
Department of rheumatology
2-1 Gion, Hakata-ku, Fukuoka 812-0038, Japan
+81-92-282-5005
info@h2-clinic.jp
Huis Ten Bosch Satellite H2 Clinic Hakata
Anicom Speciality Medical Institute
None
Self funding
Anicom Speciality Medical Institute
NO
Huis Ten Bosch Satellite H2 Clinic Hakata
Anicom Speciality Medical Institute
2018 | Year | 05 | Month | 10 | Day |
Partially published
Completed
2015 | Year | 07 | Month | 01 | Day |
2015 | Year | 07 | Month | 10 | Day |
2018 | Year | 05 | Month | 08 | Day |
2018 | Year | 05 | Month | 09 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000037078
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