Unique ID issued by UMIN | UMIN000032552 |
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Receipt number | R000037129 |
Scientific Title | Effects of smoking cessation on HDL function and cardiovascular biomarkers. |
Date of disclosure of the study information | 2018/05/11 |
Last modified on | 2020/11/12 14:03:41 |
Effects of smoking cessation on HDL function and cardiovascular biomarkers.
Smoking cessation and HDL function
Effects of smoking cessation on HDL function and cardiovascular biomarkers.
Smoking cessation and HDL function
Japan |
Nicotine addiction
Medicine in general |
Others
NO
To test whether varenicline-assisted smoking cessation for 4 weeks affect HDL levels, function, and cardiovascular biomarkers.
Efficacy
HDL cholesterol levels, cholesterol efflux capacity/antioxidant activity of HDL
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Treatment
Medicine |
varenicline treatment for 4 weeks
20 | years-old | <= |
80 | years-old | >= |
Male and Female
1) Outpatients with nicotine addiction
2) Subjects who gave written informed consent
1) Poor-controlled hypertension (DBP>110 mmHg)
2) Poor-controlled diabetes (HbA1c>8.0 %)
3) History of stroke, acute coronary syndrome or any cardiovascular diseases needed for inpatient-treatments within 6 months
4) Either level of aspartate aminotransaminase or alanine aminotransferase exceeds three-fold of the normal limits.
5) End stage renal disease
6) Symptomatic (NYHA III or IV) congestive heart failure
7) Malignancies or other diseases with poor prognosis
8) Subjects with poor-controlled psychiatric diseases
9) Subjects who are prohibited varenicline treatment
10) Subjects whose doctor in charge do not agree to join the trial
45
1st name | Makoto |
Middle name | |
Last name | Ayaori |
Tokorozawa Heart Center
Shintikoekimae Clinic
3591111
1-4-1-101 Midoricho, Tokorozawa, Saitama JAPAN 359-1111
0429291801
ayaori@ba2.so-net.ne.jp
1st name | Makoto |
Middle name | |
Last name | Ayaori |
Tokorozawa Heart Center
Shintikoekimae Clinic
3591111
1-4-1-101 Midoricho, Tokorozawa, Saitama JAPAN 359-1111
0429291801
ayaori@ba2.so-net.ne.jp
Tokorozawa Heart Center
None
Self funding
Tokorozawa Heart Center
2-61-11 Kamiarai, Tokorozawa, Saitama, JAPAN 359-1142
04-2940-8611
cs.thc@oukai.or.jp
NO
2018 | Year | 05 | Month | 11 | Day |
Unpublished
Enrolling by invitation
2017 | Year | 03 | Month | 07 | Day |
2017 | Year | 03 | Month | 07 | Day |
2018 | Year | 05 | Month | 11 | Day |
2021 | Year | 04 | Month | 30 | Day |
2018 | Year | 05 | Month | 11 | Day |
2020 | Year | 11 | Month | 12 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000037129
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