Unique ID issued by UMIN | UMIN000032668 |
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Receipt number | R000037249 |
Scientific Title | Rapid detection of Helicobacter pylori infection by g-glutamyltranspeptidase-activated fluorescent probe |
Date of disclosure of the study information | 2018/05/21 |
Last modified on | 2020/08/22 15:16:25 |
Rapid detection of Helicobacter pylori infection by g-glutamyltranspeptidase-activated fluorescent probe
Rapid detection of Helicobacter pylori infection by g-glutamyltranspeptidase-activated fluorescent probe
Rapid detection of Helicobacter pylori infection by g-glutamyltranspeptidase-activated fluorescent probe
Rapid detection of Helicobacter pylori infection by g-glutamyltranspeptidase-activated fluorescent probe
Japan |
Helicobacter pylori gastritis
Gastroenterology |
Others
NO
To investigate whether gGlu-HMRG can be useful for rapid diagnosing H. pylori infection.
Efficacy
Exploratory
Explanatory
Not applicable
Sensitivity and specificity of fluorescent probe gGlu-HMRG for Helicobacter pylori gastritis
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Diagnosis
Medicine | Other |
Biopsy from the antrum and the stomach of body
20 | years-old | <= |
Not applicable |
Male and Female
Patients who undergo esophagogastroduodenoscopy in Helicobacter pylori positive gastritis or Helicobacter pylori negative.
Unsuitable patient
50
1st name | Taro |
Middle name | |
Last name | Akashi |
Nagasaki University Hospital
Department of GASTROENTEROLOGY and HEPATOLOGY
852-8501
1-7-1 Sakamoto,Nagasaki
095-819-7481
fuk.naga.23@gmail.com
1st name | Taro |
Middle name | |
Last name | Akashi |
Nagasaki University Hospital
Department of GASTROENTEROLOGY and HEPATOLOGY
852-8501
1-7-1 Sakamoto,Nagasaki
095-819-7481
fuk.naga.23@gmail.com
Nagasaki University Hospital
None
Self funding
Nagasaki University Hospital
1-7-1 Sakamoto,Nagasaki
095-819-7481
fuk.naga.23@gmail.com
NO
2018 | Year | 05 | Month | 21 | Day |
https://www.nature.com/articles/s41598-019-45768-x
Published
https://www.nature.com/articles/s41598-019-45768-x
46
The gGlu-HMRG assay substantially elucidated H. pylori GGT activity in vitro.
The ex vivo H. pylori GGT-activatable fluorescence assay is potentially applicable for rapid diagnosis of H. pylori infections.
2020 | Year | 08 | Month | 22 | Day |
men 31, women 15.
mean age, 63.8 and 70.1 years, respectively.
All 46 participants underwent esophagogastroduodenoscopy at Nagasaki University Hospital. One biopsy was taken from the antrum and one from the body of the stomach.
none
We investigated whether gGlu-HMRG was activated by GGT produced by H. pylori cells and emit fluorescence in vitro. An ex vivo imaging assay for GGT activity with gGlu-HMRG was conducted to detect H. pylori infection using clinical samples(biopsy from the antrum and the stomach body ) .
Completed
2015 | Year | 02 | Month | 10 | Day |
2015 | Year | 02 | Month | 10 | Day |
2015 | Year | 02 | Month | 10 | Day |
2019 | Year | 07 | Month | 01 | Day |
2018 | Year | 05 | Month | 21 | Day |
2020 | Year | 08 | Month | 22 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000037249
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