Unique ID issued by UMIN | UMIN000032826 |
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Receipt number | R000037299 |
Scientific Title | Cohort study of osteoarthritis by MRI 3D analysis (Kanagawa Knee Study) |
Date of disclosure of the study information | 2018/09/01 |
Last modified on | 2024/01/07 14:39:41 |
Cohort study of osteoarthritis by MRI 3D analysis (Kanagawa Knee Study)
Cohort study of osteoarthritis by MRI 3D analysis (Kanagawa Knee Study)
Cohort study of osteoarthritis by MRI 3D analysis (Kanagawa Knee Study)
Cohort study of osteoarthritis by MRI 3D analysis (Kanagawa Knee Study)
Japan |
Adult
Adult |
Others
NO
To investigate pathology of osteoarthritis.
Others
To obtain fundamental data useful of diagnosis and treatment for osteoarthritis.
3D MRI projected cartilage area ratio by generations and transition of projected cartilage area ratio for one year.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Uncontrolled
1
Prevention
Other |
MRI, X-ray survey
30 | years-old | <= |
79 | years-old | >= |
Male and Female
1) Desk workers who can visit around Tokyo Station by themselves.
2) Workers and resignees at Kanagawa prefecture. People in Kanagawa.
3) People older than 30 years and younger than 79 years.
4) Desk workers.
1) People who cannot attend the second MRI examination one year later.
2) People who cannot obtain informed consent due to cognitive impairment.
3) People who cannot undergo MRI examination due to claustrophobia.
4) People who cannot undergo MRI examination due to metal in the body.
5) People with a history of surgery in either knee.
6) People who visited hospital for injury in either knee for more three months.
7) People who have osteoarthritis or history of fracture in either lower extremity.
8) People who are diagnosed as collagen disease such as rheumatoid arthritis.
9) People who have any knee injection or arthrocentesis.
10) People who are poor general condition.
11) People who are pregnant or possible pregnant.
12) People who have a consciousness of doing vigorous sports such as full marathon, triathlon, weight lifting.
13) People for whom involved doctors decide as not appropriate to participate in the study.
500
1st name | Ichiro |
Middle name | |
Last name | Sekiya |
Tokyo Medical and Dental University
Center for Stem cell and Regenerative Medicine
113-8510
1-5-45 Yushima, Bunkyo-ku, Tokyo
03-5803-4017
sekiya.arm@tmd.ac.jp
1st name | administrator |
Middle name | |
Last name | Office |
Tokyo Medical and Dental University
Center for Stem cell and Regenerative Medicine
113-8510
1-5-45 Yushima, Bunkyo-ku, Tokyo
03-5803-4017
saisei01.arm@tmd.ac.jp
Tokyo Medical and Dental University
Joint-research grant
Self funding
Tokyo Medical and Dental University Medical School Ethics Committee
Tokyo Medical and Dental University
03-5803-5096
syomu1.adm@tmd.ac.jp
NO
2018 | Year | 09 | Month | 01 | Day |
NONE
Unpublished
https://www.nature.com/articles/s41598-023-46953-9
573
MME was unchanged in KL grade 1 and KL grade 0, whereas it increased slightly in KL grade 2 and increased moderately in KL grade 3. Cartilage thickness first decreased in the medial tibial region in KL grade 2 subjects and in the medial femoral region in KL grade 3. Cartilage thinning occurred in the anterior central medial femoral subregion and in the anterior and middle external medial tibial subregions in KL grade 1, whereas it diffusely expanded in early and moderate knee OA.
2023 | Year | 12 | Month | 05 | Day |
469 subjects with no lateral OA from the Kanagawa Knee Study (Subjects with a history of knee OA, lower extremity trauma, previous surgery, rheumatoid arthritis, or consecutive visits to one or more hospitals for more than 3 months were excluded to remove any treatment influences).
This study was approved by the IRB of Tokyo Medical and Dental University and was conducted in accordance with the relevant guidelines/regulations. Informed consent was obtained from all participants. In addition, this study was performed in accordance with the Declaration of Helsinki.
NONE
KL grade assessed using artificial intelligence (AI) software, the MME measured by MRI, and the cartilage thickness evaluated in 18 subregions of the medial femorotibial joint by another AI system.
No longer recruiting
2018 | Year | 05 | Month | 24 | Day |
2018 | Year | 07 | Month | 27 | Day |
2018 | Year | 10 | Month | 01 | Day |
2020 | Year | 12 | Month | 31 | Day |
2018 | Year | 06 | Month | 01 | Day |
2024 | Year | 01 | Month | 07 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000037299
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