Unique ID issued by UMIN | UMIN000033202 |
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Receipt number | R000037809 |
Scientific Title | Altered brain volume in neuropathic pain patients |
Date of disclosure of the study information | 2018/07/01 |
Last modified on | 2020/02/05 20:10:43 |
Altered brain volume in neuropathic pain patients
Altered brain volume in neuropathic pain patients
Altered brain volume in neuropathic pain patients
Altered brain volume in neuropathic pain patients
Japan |
Classiccal trigeminal neuralgia and neuropathic pain due to facial trauma (painful post-traumatic trigeminal neuropathy)
Neurology | Dental medicine |
Others
NO
In the study of changes in brain volume, there are still few studies targeting pain in the oral facial pain region, and reports on the extent of changes in brain volume and areas with changes are also not consistent. In the report by Gustin et al., classical trigeminal neuralgia and neuropathic pain due to facial trauma are analyzed as the same group, but thease groups have clinical and etiologially differences. In this study, we examine the characteristics of changes in brain volume and cortical thickness of grey matter of typical trigeminal neuralgia group, neuropathic pain due to facial trauma (painful post-traumatic trigeminal neuropathy) group, control graoup of healthy subjects.
Others
Presence or absence of brain volume change when having a disease
Changes in brain volume and cortical thickness of grey matter obtained from MRI images are compared in typical trigeminal neuralgia group, painful post-traumatic trigeminal neuropathy group, control group of healthy subjects.
Interventional
Single arm
Non-randomized
Open -no one is blinded
Self control
1
Prevention
Device,equipment |
MRI examination is done once during the study period.
20 | years-old | <= |
80 | years-old | >= |
Male and Female
1. Control group: Sixty males and female healthy adults aged 20 to 80.
2. Trigeminal neuralgia group:Sixty males and female patients with classical trigeminal neuralgia aged 20 to 80 years visited the Orofacia Pain Clinic at the Tokyo Medical and Dntal University, Dental Hosipital.
3. Neuropathic pain due to facial trauma(painful post-traumatic trigeminal neuropathy)group: Sixty males and female patients with neuropathic pain due to injury of the facial area aged 20 to 80 years who visited the Orofacia Pain Clinic at the Tokyo Medical and Dntal University, Dental Hosipital.
1. Persons who have had some sort of pain in the maxillofacial area other than neuropathic pain due to trigeminal neuralgia or damage to the facial area by 4 weeks in advance. (In the control group, those who have had a history of some kind of pain in the maxillofacial area by 4 weeks before are excluded.)
2. Persons who have a history of neuraldia or psychiatric disorders in other parts. 3. Persons who have acute or chronic disease (multiple sclerosis, diabetes, herpes zoster etc.) causing pain.
4. Persons who are alcohol-dependent.
5. Persons wearing cardiac pacemakers.
6. Persons who have metals (arterial clips, intravascular stents, plates and bolts for repair and fixation, etc.) in the body.
7. Persons who are claustrophobic.
180
1st name | Masahiko |
Middle name | |
Last name | Shimada |
Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
Orofacial Pain Management
113-8548
1-5-45 Yushima Bunkyo-ku Tokyo
03-5803-4563
mshimada.ofpm@tmd.ac.jp
1st name | Yoko |
Middle name | |
Last name | Yamazaki |
Tokyo Medical and Dntal University, Dental Hosipital
Orofacial Pain Clinic
113-8549
1-5-45 Yushima Bunkyo-ku Tokyo
03-5803-5762
yamazaki-yo.ofpm@tmd.ac.jp
Tokyo Medical and Dntal University
Japan Society for the Promotion of Science
Japanese Governmental office
Dental Research Ethics Committee of Tokyo Medical and Dental University
1-5-45 Yushima Bunkyo-ku Tokyo
03-5803-5404
d-hyoka.adm@tmd.ac.jp
YES
D2014-127-02
Dental Research Ethics Committee of Tokyo Medical and Dental University
東京医科歯科大学歯学部附属病院(東京都)
2018 | Year | 07 | Month | 01 | Day |
Partially published
90
We observed a significantly smaller GMV in the right inferior temporal gyrus of both CTN and PPTN patients compared with HC. In addition, a significant GMV deficit was found in the right middle temporal gyrus in PPTN patients compared with HC. We also observed a smaller GMV in PPTN compared with CTN in the temporal and parietal cortices. Pain duration was negatively correlated with GMV in PPTN patients.
2020 | Year | 02 | Month | 05 | Day |
Terminated
2014 | Year | 09 | Month | 17 | Day |
2015 | Year | 03 | Month | 13 | Day |
2015 | Year | 03 | Month | 13 | Day |
2020 | Year | 03 | Month | 31 | Day |
2018 | Year | 06 | Month | 29 | Day |
2020 | Year | 02 | Month | 05 | Day |
Value
https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000037809
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